Forward models can predict sensory consequences of self-action, which is reflected by less neural processing for actively than passively generated sensory inputs (BOLD suppression effect). However, it remains open whether forward models take the identity of a moving body part into account when predicting the sensory consequences of an action. In the current study, fMRI was used to investigate the neural correlates of active and passive hand movements during which participants saw either an on-line display of their own hand or someone else's hand moving in accordance with their movement. Participants had to detect delays (0-417 ms) between their movement and the displays. Analyses revealed reduced activation in sensory areas and higher delay detection thresholds for active versus passive movements. Furthermore, there was increased activation in the hippocampus, the amygdala, and the middle temporal gyrus when someone else's hand was seen. Most importantly, in posterior parietal (angular gyrus and precuneus), frontal (middle, superior, and medial frontal gyrus), and temporal (middle temporal gyrus) regions, suppression for actively versus passively generated feedback was stronger when participants were viewing their own compared to someone else's hand. Our results suggest that forward models can take hand identity into account when predicting sensory action consequences. K E Y W O R D Sagency, fMRI, forward model, hand identity, hand movement, prediction, self-other

Schizophrenia spectrum disorders (SSD) are characterized by disturbed self-other distinction. While previous studies associate abnormalities in the sense of agency (ie, the feeling that an action and the resulting sensory consequences are produced by oneself) with disturbed processing in the angular gyrus, passive movement conditions to isolate contributions of motor predictions are lacking. Furthermore, the role of body identity (ie, visual features determining whether a seen body part belongs to oneself) in self-other distinction is unclear. In the current study, fMRI was used to assess the roles of agency and hand identity in self-other distinction. Patients with SSD and healthy controls (HC) performed active and passive hand movements (agency manipulation) while seeing their own or someone else’s hand moving in accordance with their action (hand identity manipulation). Variable delays (0–417 ms) between movement and feedback had to be detected. Our results showed overall lower delay detection performances during active than passive conditions; however, these differences were reduced in patients when the own hand was displayed. On a neural level, we found that in HC, activation in the right angular gyrus was modulated by agency and hand identity. In contrast, agency and hand identity revealed no overlapping activation in patients, due to reduced effects of agency. Importantly, HC and SSD patients shared similar effects of hand identity in the angular gyrus. Our results suggest that disturbances of self-other distinction in SSD are particularly driven by agency, while self-other distinction based on hand identity might be spared.

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