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Background/Aim: Ethnicity has an effect on survival in patients with pancreatic adenocarcinoma (PDAC), which may be reflected in the rate of somatic driver mutations. The Brazilian population represents au extensive interethnic admixture and little is known about the spectrum and rates of somatic driver mutations in Brazilian PDAC cases. Materials and Methods: Direct sequencing of six genes in 23 PDAC cases was performed and the ancestry of patients was determined using a validated panel of ancestry-informative insertion/ deletion DNA polymorphisms. Results: KRAS proto-oncogene (KRAS) was the most commonly mutated gene (60%). A novel putatively pathogenic mutation in phosphatidylinositol-4,5bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) (c.2948T>A; p.M983K) was identified. Mutations in epidermal growth factor receptor (EGFR) (4%), PIK3CA (4%), cyclindependent kinase inhibitor 2A (CDKN2A) (4%) and TP53 (8%) were noted, in rates that are less frequent than those reported for other populations. Mutations of B-Raf proto-oncogene, serine/threonine kinase (BRAF) were not present. All individuals with high African ancestral component (allelic frequency, >0.45) exhibited KRAS mutations. Conclusion: Our results highlight the importance of the effect of ethnicity on somatic mutations in Brazilian patients with PDAC. References 1 Coupland VH, Kocher HM, Berry DP, Allum W, Linklater KM, Konfortion J, Moller H and Davies EA: Incidence and survival for hepatic, pancreatic and biliary cancers in England between

Schizophrenia is a chronic mental illness quite present in Brazilian society, but it does not have the care and attention necessary to make the patient's well-being satisfactory. It has a very complex pharmacodynamics, where without proper care, can cause adverse effects that may harm the health of the patient. Therefore, the objective of this study is to evaluate in the last five years the leukogram profile of patients with refractory schizophrenia who use clozapine assisted in the Specialized Component of Pharmaceutical Care of Piauí, by analyzing data that will be collected through the evaluation of medical records. analyzing and verifying that the leukogram levels of these patients are within the parameters recommended by the literature. They were then checked in the SOFTWARE PRISMA 6.0 program. The results showed that of the analyzed charts, regarding gender, 64% were men and 36% were women. There was an incidence of agranulocytosis and the highest age was 31 to 40 years. Drug change and the incidence of neutropenia, thrombocytopenia and eosinophilia were also observed in some patients. Thus, it can be suggested that patients with refractory schizophrenia treated in the Specialized Component of Pharmaceutical Care of Piauí, are having a multiprofessional follow-up, especially the pharmacist who provides patient care at the time of dispensation, very effective.

In this work, barium titanate powders were produced by sol-gel and sol-precipitation methods from metal alkoxides. In the sol-gel method, tetraisopropyl orthotitanate was mixed with 2-propanol, acetic acid and barium acetate, and the gel samples obtained were calcined at 600 °C, 800 °C and 1000 °C. Through the sol-precipitation method, tetraisopropyl orthotitanate was mixed with acetic acid and deionized water and precipitated by the addition of a concentrated solution of KOH. The products were calcined at various temperatures, and the microstructural and dielectric properties of the BaTiO3 prepared for the two processes were analyzed and compared. The results of these analyses allowed us to observe an increase in the tetragonal phase and the dielectric constant (15–50 at 20 kHz) with increasing temperatures in the samples produced by the sol-gel method, while the sample obtained by sol precipitation was cubic. The presence of BaCO3 is more evident in the sample produced by sol-precipitation, and the band gap of the products obtained did not show significant variation, changing the synthesis method (3.363–3.594 eV).