Versión / Versió:Preprint
Conflict of Interest (COI) StatementThe authors of the present manuscript declare no conflict of interest.
AbstractDue to its capital role in drug seeking, consumption and addictive behaviour there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug related memories. Human studies focused on neuronal systems that store and control drug-conditioned memories have found cerebellar activations during the retrieval of drug-associated cues memory. However, at the preclinical level, almost no attention has been paid to a possible role of the cerebellum in drug-related memories. In the present study, we ought to fill this gap by aiming to investigate the pattern of neuronal activation (as revealed by cFos expression) in different regions of the prefrontal cortex and cerebellum of mice trained to develop conditioned preference for an olfactory stimulus (CS+) paired with cocaine.Our results indicate that CS+ preference was directly associated with cFos expression in cells at the apical region of the granule cell layer of the cerebellar vermis, this relationship being more prominent in some specific lobules. Conversely, cFos+ immunostaining in other cerebellar regions seems unrelated to CS+ preference but to other aspects of the conditioning procedure. At the prefrontal cortex, cFos expression seemed to be related to cocaine administration rather than to its ability to establish conditioned preference. The present results suggest that as it has been observed in some clinical studies, the cerebellum might be an important and largely overlooked part of the neural circuits involved in generating, maintaining and/or retrieving drug memories.
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