Immunocompromised patients frequently present a prolonged viral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA detection in respiratory samples and are unrecognized sources of transmission. It is therefore important to determine their infectivity potential to establish the adequate follow-up and quarantine measures. We present a test-based strategy to follow up an immunocompromised patient fully vaccinated for SARS-CoV-2, diagnosed with COVID-19 that 3 months after reaching the clinical criteria of cure presented a reduced cycle threshold value in a real-time polymerase chain reactive SARS-CoV-2 test and a positive antigen SARS-CoV-2 test, while being asymptomatic.
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