Background/Aims: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. Results: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZinduced diabetic rats by reduction of renal fibrosis. Conclusion: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.
In vitro activity of the essential oil from Piper diospyrifolium leaves was tested using disk diffusion techniques. The antifungal assay showed significant potencial antifungal activity: the oil was effective against several clinical fungal strains. The majority compounds in the essential oil were identified as sesquiterpenoids by GC-MS and GC-FID techniques.
RESUMOObjetivo: evidenciar fortalezas e fragilidades da família no cuidado à criança dependente de tecnologia e mudanças ocorridas após o retorno da criança ao domicílio; discutir desafios e possibilidades para a inserção familiar no processo assistencial de saúde. Método: descritivo de abordagem qualitativa, realizado com famílias de crianças doentes crônicas dependentes de tecnologia em um município do sul do Brasil.As informações obtidas foram tratadas conforme o referencial metodológico da Análise de Conteúdo, modalidade temática e o referencial teórico do Interacionismo Simbólico. Resultados: a análise dos dados convergiu em cinco categorias temáticas, as quais foram exploradas e discutidas. Conclusão: o estudo permitiu conhecer os significados atribuídos pela família à experiência de cuidar de uma criança dependente de tecnologia, identificando as fragilidades do cuidado e lacunas no apoio dos serviços de saúde.
We evaluate the biological and physicochemical effects of a Fusarium oxysporum crude extract (CE) on the skin of healthy rats. The CE is topically applied and subsequently the skin is collected after 3, 6, 12, and 24 h. The samples are analyzed by Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS) and histomorphometric analysis. Terminal dUTP nick end labeling (TUNEL assay) is performed to detect both the cells in apoptosis and proliferation. There is a thickening of the epidermis after 6, 12, and 24 h and dermis after 12 and 24 h of CE application. A reduction of the dermis thickness is observed at 3 and 6 h. The treated skin shows higher labeling intensity by TUNEL at 3 h, while a higher intensity by proliferating cell nuclear antigen occurs at 3 and 12 h. FTIR-PAS data support the histology observations showing an increase in the absorption peaks in the dermis after the application of the CE. F. oxysporum CE permeated through the epidermis and the dermis, reaching the subcutaneous tissue, inducing cell apoptosis, and causing physicochemical changes in the organic molecules located in the dermis. This is the first known study associating histopathological and physical chemistry changes on healthy skin after the application of F. oxysporum CE.
Resumo As infecções urinárias estão entre as infecções mais comuns e acomete muitos pacientes que procuram os serviços de saúde. Quando não diagnosticadas e tratadas precocemente evoluem para doenças mais graves, dentre elas a mais comum a pielonefrite, que acomete o tecido renal com complicações graves como a insuficiência renal crônica e a hipertensão, acarretando em maior gasto dos serviços de saúde com o tratamento. As infecções do trato urinário podem ser classificas em: cistites, bacteriúria de baixa e alta contagem, síndrome uretral, contaminação urinária e pielonefrite não complicada ou complicada. Dentre os principais métodos de diagnostico encontram-se os exames parcial de urina acompanhado ou não de urocultura, exames bioquímicos que avaliam a função renal, ultrassom das vias urinárias e cintilografia, além de biópsia do tecido renal. Sabendo disso, o presente estudo busca definir as características das infecções urinárias em especial a pielonefrite, bem como seus conceitos, diagnóstico e tratamento, através de revisão bibliográfica da literatura com consulta a bases de dados PubMed e Scielo, sobre o assunto infecções urinárias e pielonefrite. Com isso, agregar conhecimento sobre diferentes definições e agravos relacionados as complicações das infecções urinárias, como também demonstrar estratégias que possam minimizar os gastos públicos com tratamentos honerosos e prolongados, devido sua baixa resolutividade.
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