The aim of this study is to evaluate the efficacy and viability of hypnosis before and during a gastrointestinal endoscopy. Six Gastroscopies and 22 colonoscopies were carried out under hypnosis in a group of patients. The patients ranged in age from 20 and 67 years and have a history of previously incomplete and poorly tolerated examinations or expressed an active demand for sedation. For 6 of the patients who underwent a gastroscopy under hypnosis, the procedure was successfully completed, reaching the second part of the duodenum without difficulty for the endoscopist. Colonoscopy of the cecum was completed in 19 of 20 patients. All patients, except 1, considered their tolerance level as "good." Hypnosis facilitated an adequate endoscopy intervention without any discomfort in 85% of the cases examined. Avoidance of anaesthesia reduces risk to the patient. Hence, hypnosis for gastrointestinal endoscopy appears to provide a promising strategy.
BACKGROUND.We present a clinical trial to assess the hypothesis that chemotherapy related acute emesis is reduced when drugs are delivered while the patient is sleeping.
METHODS.Adults without previous sleep disturbances or vomit inducing conditions who were going to receive their first courses of 100 mg/mz cisplatin were included. We reduced antiemetic prophylaxis consisting of ondansetron and dexamethasone in subsequent groups of patients.
RESULTS.Twenty-one individuals were needed to decrease the antiemetic prophylaxis to zero. Significant vomiting was observed only when prophylaxis was abolished but not in previous steps employing negligible doses of prophylaxis.
CONCLUSIONS.Our data show that when cisplatin is administered during sleep, the reduction of antiemetic prophylaxis is not followed by the expected increase in emetic toxicity. This antiemetic property of sleep is, as far as we know, unassessed in a controlled way. Further study of the clinical utility of this method in the prevention of chemotherapy related emesis is indicated.
After medical and genetic screening, docturnal polysomnography followed by a Multiple Sleep Latency Test and HLA typing were performed. The patient was medication free and reported a number of cataplexy attacks everyday. Each time that she came to the sleep disorders clinic, she was observed to have cataplexy. She also felt extremely drowsy. A mean sleep latency of 8.8 minutes with 4 sleep-onset rapid eye movement periods in the Multiple Sleep Latency Test, with no other sleep disorder that accounts for the symptoms, was obtained. The patient was DQB1*0301, DQB1*0602, as revealed by the last high-resolution serologic typing.
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