Background: Colorectal malignancies are common, with adenocarcinoma as the most prevalent type. Recently, studies of specific morphology like tumor budding have already started and related with tumor's aggressivity as well as several parameters. This study aims to evaluate the association between tumor budding grade with patient age, sex, tumor location, histological grade, depth of invasion, and nodal status in colorectal adenocarcinoma at Sanglah General Hospital. Methods: This cross-sectional descriptive study used samples of intestinal resection specimens accompanied by Regional Lymph Node (RLN) removal of colorectal adenocarcinoma patients at Sanglah Hospital in 2018-2020. The sampling technique was carried out consecutively, which met the inclusion and exclusion criteria. Data on age, sex, tumor location, histologic grade, depth of invasion, and nodal status were Latar Belakang: Kanker kolorektal merupakan keganasan yang sering ditemukan dengan adenokarsinoma merupakan tipe histopatologi terbanyak. Dewasa ini telah mulai diteliti morfologi spesifik yaitu tumor budding yang dikaitkan dengan agresivitas tumor maupun parameter lainnya. Penelitian ini bertujuan untuk mengetahui hubungan antara tumor budding grade dengan umur pasien, jenis kelamin, lokasi tumor, grade histopatologi, kedalaman invasi, dan status nodal pada adenokarsinoma kolorektal di RSUP Sanglah Denpasar. Metode: Penelitian deskriptif potong lintang ini menggunakan sampel spesimen reseksi usus disertai pengangkatan Kelenjar Getah Bening (KGB) regional pasien adenokarsinoma kolorektal di RSUP Sanglah tahun 2018-2020. Teknik pengambilan sampel
Background: Photoaging increases MMP-1 and damage collagen by forming ROS. The antioxidant compounds in Clitoria ternatea L. have been studied to lower ROS, thus inhibiting the emergence of MMP-1 and preserving the collagen. The study initiated to analyze the Clitoria ternatea L. extract cream 5% effect on inhibiting MMP-1 increase and collagen decrease in female Wistar rat's skin exposed to UV-B. Methods: A randomized post-test-only control group design was conducted on 30 female Wistar rats, aged 8-10 weeks old with 130-150 grams bodyweight. They were assigned to three groups: the untreated group, placebo group, and the Clitoria ternatea L. extract cream 5% group. The last two groups were exposed to UV-B. After four weeks their skin was examined for MMP-1 levels using ELISA and collagen amount using Picro Sirius Red staining. Results: A comparative analysis showed that the lowest mean levels of MMP-1 was seen in the untreated group (4.64 ± 0.14 ng/ml), followed by the Clitoria ternatea L. extract cream group 5% (5.54 ± 0.21 ng/ml) and placebo group (8.68 ± 0.78 ng/ml). The highest mean of collagen amount was seen in the Clitoria ternatea L. extract cream group 5% (76.12 ± 5.09 %pixel), followed by the untreated group (69.38 ± 3.96 %pixel) and placebo group (30.31±8.06 %pixel). The comparative analysis shows a significant difference between groups (p < 0.05). Conclusion: The Clitoria ternatea L. extract cream 5% has proven to inhibited the increase of MMP-1 levels and decrease of collagen amount in Wistar rats skin exposed to UV-B.
Reporting two cases of mixed adenocarcinoma and neuroendocrine carcinoma of the ovary. A case report two cases of an ovarian cyst suspect malignancy after complete surgical staging in woman aged 39 year old and 72 year old. By this case report, we want to know prognosis of the malignancy. Mixed adenocarcinoma and neuroendocrine carcinoma of the ovary of the first case arised from mature cystic teratoma, and second case as metastatic process from gastrointestinal tract. Mixed adenocarcinoma and neuroendocrine carcinoma is rare hystologic type of ovarian cancer. Need further exploration to know the survival of this hystologic type.ABSTRAKArtikel ini melaporkan dua kasus, yaitu mixed adenocarcinoma dan neuroendocrine carcinoma ovarium, dua kasus kista ovarium curiga ganas pada pasien berusia 39 tahun dan 72 tahun. Terhadap kedua pasien dilakukan komplit surgical staging. Melalui laporan kasus ini, diharapkan bisa diketahui prognosis kasus. Mixed adenocarcinoma dan neuroendocrine carcinoma ovarium pada kasus pertama timbul dari teratoma matur kistik, sedangkan kasus kedua merupakan penyebaran dari traktus digestivus. Mixed adenocarcinoma dan neuroendocrine carcinoma merupakan tipe histologi kanker ovarium yang jarang. Ia membutuhkan eksplorasi lebih lanjut untuk mengetahui survival dari tipe histologi ini.
Background: Colorectal carcinoma is a malignant epithelial tumor of the large bowel that occurs due to extrinsic and intrinsic factors. BRAF V600E gene mutation was found in about 10-15% of colorectal carcinoma. This mutation was associated with aggressive biologic behaviors, metastasis and lesser responsiveness to EGFR inhibitors therapy. This study aims to determine the association between BRAF V600E expression with metastasis and the degree of differentiation of colorectal adenocarcinoma. Methods: This cross sectional study involved 43 samples of adenocarcinoma colorectal patients who had histopathological examinations in the period 2018-2019. Immunohistochemical were performed to assess the expression of BRAF V600E. This expression was concluded positively if 75% or more tumor cells showed intense cytoplasmic staining. Data were analyzed using
Background: Lymph Node Metastasis (LNM) is considered the most important prognostic factor in breast cancer. The progress of lymphatic metastasis is thought to involve the proliferation of lymphatic vessels (lymphangiogenesis), Lymph Vessel Invasion (LVI), and lymph node metastasis step by step. This study aims to evaluate the association between LVD with LVI and regional LNM in invasive breast carcinoma of no special type. Methods: This study used a cross-sectional analytical study, using a sample of 38 paraffin-embedded tissue from the patient with invasive breast carcinoma of no special type in Sanglah General Hospital, Bali, Indonesia, in 2018. The sample will be used to assess LVD and LVI by D2-40 immunohistochemistry. Expression of D2-40 with vigorous-intensity was evaluated on the membrane and cytoplasm of lymphatic endothelial cells to determine the definition of lymphatic vessels. Lymph vessel density was determined by counting the Latar Belakang: Metastasis Kelenjar Getah Bening (KGB) dianggap sebagai faktor prognostik yang paling penting pada kanker payudara. Perkembangan metastasis limfatik diduga melibatkan proliferasi pembuluh limfatik (limfangiogenesis), Lymph Vessel Invasion (LVI) atau invasi limfatik, dan metastasis kelenjar getah bening secara bertahap. Penelitian ini bertujuan untuk mengevaluasi hubungan antara Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik. Metode: Penelitian ini menggunakan metode analitik number of lumens of peritumoral lymphatic vessels in five fields of view with the densest lymphatic vessel lumen using a Leica microscope (DM750, 400x, area 0.225mm2). Data were analyzed using SPSS version 24 for Windows. Results:The LVD cut-off value is 16.5 lymphatic vessel lumens/0.225 mm2 (65.4% for sensitivity and area Under the Curve (AUC)=70.2%). Then cases were classified into the category of high LVD (≥16,5 lymphatic vessel lumen/0,225 mm 2 ) and low LVD (<16.5 lymphatic vessels lumen/0,225 mm 2 ). The study found a statistically significant association between LVD and lymph vessel invasion (PR=3.6; p=0.043; 95%CI=0.88-14.78) and regional lymph node metastases (PR =1.7; p=0.02; 95%CI=1. 03-2.79). Conclusion:This study proved an association between LVD with lymph vessel invasion and regional lymph node metastases. potong lintang dengan sampel 38 blok parafin dari pasien karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia tahun 2018. Penilaian LVD dan LVI dengan pulasan imunohistokimia D2-40. Ekspresi D2-40 dengan intensitas yang kuat dievaluasi pada membran dan sitoplasma sel endotel limfatik untuk menetapkan definisi pembuluh limfatik. Lymph vessel density ditentukan dengan menghitung jumlah lumen pembuluh limfatik peritumoral pada lima lapangan pandang yang memiliki lumen pembuluh limfatik terpadat, menggunakan mikroskop Leica (DM750, 400x, luas area 0,225mm 2 ). Data dianalisis
Background: Vascular Endothelial Growth Factor (VEGF) is an angiogenic factor that plays an important role in tumor angiogenesis. VEGF in meningioma is up-regulated and indicates its role as a proangiogenic factor. It has an association with tumor recurrence and progression. This study aims to determine the differences in VEGF expression in low-risk and highrisk meningiomas at
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.