Abstract-The effect of galardin, a broad-spectrum matrix metalloproteinase (MMP) inhibitor, was studied in mice kept on a high fat diet (HFD). Five-week-old male wild-type mice were fed the HFD (42% fat) for up to 12 weeks and were daily injected intraperitoneally with the inhibitor (100 mg/kg) or with vehicle. After 12 weeks of the HFD, the body weights of both groups were comparable, but the weight of the isolated subcutaneous (SC) or gonadal (GON) fat deposits was significantly lower in the inhibitor-treated group than in the control group (88Ϯ11 versus 251Ϯ66

Groin injuries are becoming more common today in soccer. Conservative treatment consisting of rest, physiotherapy, and medication yields favorable results in only 38% of the long-standing lesions. Operative treatment is indicated in selected cases. Better knowledge of the underlying pathology and a more accurate initial conservative treatment directed to the ethiopathogenesis could solve many of the problems. However, in our experience a simple subcutaneous adductor tenotomy and/or a rectus abdominis tenotomy in combination with a fasciaplasty was done successfully in 75 of 81 patients. There was no loss of power in this group of patients as measured and compared with a control group.

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