high-risk patients. We would suggest starting the screening for MBD from DOL 15 with serum ALP levels greater than 500 UI/L. Therefore, treatment based on supplementation with phosphorus and/or calcium (to reach total intakes of 90 and 150 mg/kg/d, respectively), as suggested in previous studies [1,4], could be administered earlier to the patients exhibiting biological signs of ongoing MBD.
DeclarationsEthics Approval "French Advisory Committee for the Protection of People" and "Commission Nationale de l'Informatique et des Libertés" n°2051804.Informed Consent Informed consent was obtained from legal guardians.
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