A distinctive species, Vanilla denshikoira, is described from the North West Amazon, in Colombia, within the Guiana Shield region. The species has morphological features similar to those of species in the Vanilla planifolia group. It is an important addition to the vanilla crop wild relatives, bringing the total number of species in the V. planifolia group to 21. Vanilla denshikoira is a narrow endemic, known from only a single locality, and highly vulnerable to anthropological disturbance. Under IUCN criteria it is categorized CR. The species has potential value as a non-timber forest product. We recommend a conservation program that includes support for circa situm actions implemented by the local communities.