Aim To identify and evaluate psychometric properties of assessment tools for assessing pain interference in children, adolescents, and adults with chronic pain and the inability to self‐report. Method The protocol was registered with PROSPERO (CRD42022310102). A search was run in MEDLINE, Embase, and PsycInfo (29th March 2022) to identify articles reporting psychometric properties of pain interference assessment tools for children, adolescents, and adults with chronic pain and the inability to objectively self‐report pain. Retrieved studies were reviewed by two authors (MGS, LCF) and study quality was assessed using COSMIN. Results Psychometric properties of 10 pain interference tools were assessed from 33 studies. The Paediatric Pain Profile (PPP) had low‐quality evidence for content validity and internal consistency with children and adolescents who are unable to self‐report. No tools for adults had evidence for content validity and internal consistency. No tool had evidence for all nine psychometric properties. Interpretation The PPP is recommended for pain interference assessment in children and adolescents with chronic pain and the inability to self‐report. Few tools are available for adults. Three tools for children (Patient‐Reported Outcome Measurement Information System Pediatric Proxy Pain Interference Scale; Bath Adolescent Pain Questionnaire for Parents; modified Brief Pain Inventory‐Proxy [mBPI]) and three tools for adults (Doloplus‐2; Patient‐Reported Outcome Measurement Information System Pain Interference Scale‐proxy; Brief Pain Inventory‐proxy) are promising but require further investigation.
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