The prevalence of the classical form was 58.3% in group 1 and 66.7% group 2 (p=0.736); atypical CD 41.7% vs 31.1% (p=0.509). Moderate and severe epigastric pain was common in both groups: 50.0% vs 31.1% (p=0.309). Significantly elevated level of anti-tTG antibodies (>100RU/ml) was detected equally in groups: 33.3% vs 47.7% (p=0.516). The prevalence of elevated level of antiparietal antibodies in groups was the same: in group 1-anti-H+/K+ ATPase antibodies in 2 children and in 3 children in group 2; and anti-intrinsic antibodies in 1 person in group 1 as in group 2. Thus, 25% vs 8.7% (p=0,078). Conclusion There are conflicting studies results regarding the association between H. pylori and CD. Whether Helicobacter pylori triggers, doesn't affect or protects against CD is currently the subject of research. This study didn't reveal any effects of H. pylori on course of celiac disease in children despite the fact, that H. pylori is suspected as possible trigger of autoimmunity.
In this work the application of CellDesigner 4.0 (Systems Biology Institute, Tokyo, Japan) for nutrition planning and food safety control was tested using three models: (i) metabolic model ofglycolysis, (ii) folate-mediated 1-carbon metabolism and (iii) metabolism of arsenic in humanliver. Each model was simulated with a few different initial nutrient concentrations and enzyme activities. After model design and simulations in CellDesigner, it can be concluded that the use of computational tools enablefast and reproducible analysis of different input concentrations and different enzyme activity effects on specific metabolic process in the human organism. Application of computational modelling for nutrient related pathway analysis ensures a detail insight in metabolic process and simple control of the metabolic reaction affectedby nutrient intake. Computational approach also simplifies prediction of potential hazards in foods, as demonstratedby metabolism ofarsenicexample.
Adherence to the Mediterranean diet (MD) has been found beneficial for the prevention and treatment of various chronic non-communicable diseases; however, adherence to MD is declining, especially in the Mediterranean countries. Croatia is characteristic for having both traditionally continental and Mediterranean regions, with distinct dietary features. The aim of this study was to compare difference in adherence to MD and overall dietary intake between children and adolescents from continental and Mediterranean part of Croatia. Participants were randomly recruited children and adolescents (n=838, mean age 9.96 ± 2.09 years) located in continental and Mediterranean parts of Croatia. Three different questionnaires were distributed and collected: general questionnaire (age and gender), the Mediterranean Diet Quality Index for children and adolescents (KIDMED) and 3-day food records (3DFR). Statistical analysis was performed using SPSS 260 (IBM Corporation, Chicago, Illinois, USA) statistical software. P values less than 0.05 were considered significant. Overall, low adherence to MD was evident in 23.1% of participants, while only 15.8% of children and adolescents had good compliance with MD. A significant difference in KIDMED score has been found between the continental (mean score 4.91 ± 2.33) and Mediterranean (mean score 5.57 ± 2.12) part of Croatia (p<0.001), as well as in the intake of energy and some nutrients. Moreover, participants from the Mediterranean part of Croatia had better compliance with D-A-CH recommendations for some nutrients compared to those from the continental part. Although children and adolescents from the Mediterranean part of Croatia had better adherence to MD than those from the continental part, overall, relatively poor adherence to MD was evident for both regions. Therefore, a healthy, balanced diet should be encouraged in both regions, preferably taking into account traditionally consumed and locally available foods.
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