Objectives: This paper aims to discuss some important aspects of surgical planning and treatment of some syndromes with maxillofacial implications. Methods: A case series of five different syndromes with maxillofacial implications was reported. We searched MEDLINE for a surgical approach to these maxillofacial syndromes. PROCESS guidelines have been adopted for the current case series. A Pearson correlation test was performed and considered significant only with a 95% confidence interval. Discussion: The number of publications on the subject of maxillofacial surgery is not related to the incidence of the reported syndromes. Surgical planning and treatment have been discussed in cases of Eagle´s syndrome, Jacob´s disease, Crouzon syndrome, Cleidocranial dysplasia, and Goldenhar syndrome. A brief report of the features of the syndrome and surgical procedures involved were evaluated. Conclusions: Styloidectomy and coronoidectomy are considered the best treatments for Eagle´s syndrome and Jacob´s disease, respectively. For some syndromes, tailored surgical treatment is essential. Some data must be considered in surgical planning and treatment. Depending on one characteristic or another, the surgical procedure can be chosen.
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