The MetaCyc database (MetaCyc.org) is a freely accessible comprehensive database describing metabolic pathways and enzymes from all domains of life. The majority of MetaCyc pathways are small-molecule metabolic pathways that have been experimentally determined. MetaCyc contains more than 2400 pathways derived from >46 000 publications, and is the largest curated collection of metabolic pathways. BioCyc (BioCyc.org) is a collection of 5700 organism-specific Pathway/Genome Databases (PGDBs), each containing the full genome and predicted metabolic network of one organism, including metabolites, enzymes, reactions, metabolic pathways, predicted operons, transport systems, and pathway-hole fillers. The BioCyc website offers a variety of tools for querying and analyzing PGDBs, including Omics Viewers and tools for comparative analysis. This article provides an update of new developments in MetaCyc and BioCyc during the last two years, including addition of Gibbs free energy values for compounds and reactions; redesign of the primary gene/protein page; addition of a tool for creating diagrams containing multiple linked pathways; several new search capabilities, including searching for genes based on sequence patterns, searching for databases based on an organism's phenotypes, and a cross-organism search; and a metabolite identifier translation service.

We propose a novel framework for speaker recognition in which extraction of sufficient statistics for the state-of-the-art i-vector model is driven by a deep neural network (DNN) trained for automatic speech recognition (ASR). Specifically, the DNN replaces the standard Gaussian mixture model (GMM) to produce frame alignments. The use of an ASR-DNN system in the speaker recognition pipeline is attractive as it integrates the information from speech content directly into the statistics, allowing the standard backends to remain unchanged. Improvement from the proposed framework compared to a state-of-the-art system are of 30% relative at the equal error rate when evaluated on the telephone conditions from the 2012 NIST speaker recognition evaluation (SRE). The proposed framework is a successful way to efficiently leverage transcribed data for speaker recognition, thus opening up a wide spectrum of research directions.

The Speakers in the Wild (SITW) speaker recognition database contains hand-annotated speech samples from open-source media for the purpose of benchmarking text-independent speaker recognition technology on single and multi-speaker audio acquired across unconstrained or "wild" conditions. The database consists of recordings of 299 speakers, with an average of eight different sessions per person. Unlike existing databases for speaker recognition, this data was not collected under controlled conditions and thus contains real noise, reverberation, intraspeaker variability and compression artifacts. These factors are often convolved in the real world, as the SITW data shows, and they make SITW a challenging database for single-and multispeaker recognition

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