Intramuscular injections of ketamine-acepromazine provided satisfactory surgical levels of anaesthesia. Induction was smooth. There was a wide margin of safety with no significant side effects, and there were no deaths attributable to anaesthesia. Induction time was 4-6 min, duration of surgical anaesthesia was 40-60 min, with complete recovery in 2-5 h. 80 chinchillas were used for this study.
Since the monaural chinchilla has proven to be an excellent subject for research in audition, the present study sought to assess possible changes in the audibility curve resulting from surgically rendering the chinchilla monaural. Nine chinchillas were trained to respond to six pure tones by the method of instrumental avoidance conditioning, after which threshold testing was conducted using a modified method of limits. After establishing the audibility curve of the binaural chinchillas, sterile surgery was performed to destroy the left cochlea of each animal. When recovery from surgery was complete, the animals were retrained and retested. Auditory sensitivity for tones spaced at octave steps from .25 to 8.0 kHz was found to decrease by a factor of 5 dB on the average 'as a result of the surgical procedure (range = 2.6-8.06 dB).
Monaural chinchillas trained in behavioral audiometry. were used to test the hypothesis that the combined effects of noise and sodium salicylate intoxication produce a larger loss of hearing sensitivity or temporary threshold shift (TTS) than either agent alone can produce. The hypothesis was confirmed in that, while the TTS due to broad-band noise exposure of 85-dB intensity was 35 dB on the average. and the TTS, due to prolonged serum salicylate levels of approximately 20•40 mg%. was 33 dB on the average. the combination of noise and salicylate exposure produced a TTS of 55 dB on the average.
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