Background Salivary urea concentrations correlate with serum urea concentrations in dogs and humans. Salivary urea concentrations can now be determined semi‐quantitatively using a salivary urea test strip method that has been validated for use in humans. Objectives We aimed to evaluate the repeatability of the salivary urea test strip score, and the correlation between the salivary urea test strip scores and serum urea concentrations in dogs. Methods Intra‐run and inter‐run variabilities were determined (n = 10 in triplicate). Correlations between salivary urea test strip scores and serum urea concentrations in dogs were assessed using the Spearman's correlation coefficient. Receiver operator curve analysis was used to evaluate the diagnostic performance of the salivary urea test strip score to identify dogs with serum urea concentration >7.4 mmol/L (upper limit of laboratory RI). Results The intra‐run repeatability was good (28/30 concordant results) whereas the inter‐run repeatability was moderate (23/30 concordant results). Salivary and serum urea concentrations showed a moderately positive correlation (rs = .63, n = 33; P < .0001). A salivary urea test strip score ≥4 was 57% sensitive and 96% specific for detecting a serum urea concentration >7.4 mmol/L. Conclusions Uremia can be detected using salivary urea test strips in dogs. Based on our preliminary data, salivary urea test strip scores of 1 or 2 might exclude clinically relevant uremia in most cases; however, it is recommended that the salivary urea test be repeated in dogs with a test strip score of 3. Dogs with a salivary urea test strip score of ≥4 would likely require additional investigations.
This case report describes an atypical presentation of cryptococcal infection in a cat initially presented with multiple persistent pruritic exudative skin lesions, which did not subside following administration of antibiotics and corticosteroids. Both fungal culture and feline immunodeficiency virus (FIV)/feline leukaemia virus (FeLV) ELISA test yielded negative results. Cytological examination of the skin scrapings was consistent with infection by Cryptococcus, which was confirmed by both postmortem inspection and histopathological examination of the lesions. The observed multifocal skin lesions are the result of haematogenous dissemination of the yeast, which is generally seen in immunocompromised cats. Clinical signs of systemic infection by Cryptococcus include apathy and cachexia and may or may not follow classical nasal disease. Surprisingly, the cat described in this report was immunocompetent, presented in good general condition and with no nasal discharge.
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