Objectives To investigate the association between environmental tobacco smoke, plasma cotinine concentration, and respiratory cancer or death.

These data indicate that FLNA is crucial for D2R expression and signaling in lactotrophs, suggesting that the impaired response to DA may be related to the reduction of FLNA expression in DA-resistant prolactinomas.

No abstract

Objective: The use of late-night salivary cortisol (LNSalC) for diagnosing subclinical hypercortisolism (SH) is debated. No data are available regarding the role of LNSalC as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in SH diagnosis. The aim of this study was to evaluate the diagnostic accuracy of LNSalC measured by LC-MS/MS in SH. Design: Cross-sectional prospective study of outpatients. Methods: In 70 consecutive patients with adrenal incidentalomas (AI), without signs and symptoms of hypercortisolism, we diagnosed SH in the presence of at least two of the following: cortisol after 1 mg overnight dexamethasone suppression test (1 mg DST) O83 nmol/l, 24-h urinary free cortisol (UFC) O193 nmol/24 h, and morning ACTH !2.2 pmol/l. The LNSalC levels by LC-MS/MS at 2300 h (normal values !2.8 nmol/l) and the presence of hypertension, type 2 diabetes mellitus (T2DM), and osteoporosis (OP) were assessed. Results: The increased LNSalC levels (O2.8 nmol/l) had an 83.3% specificity (SP) and a 31.3% sensitivity (SN) for predicting the biochemical diagnosis of SH. The increased LNSalC had an 85.2% SP and a 55.6% SN for predicting the presence of hypertension, T2DM, and OP, while the combination of LNSalC O1.4 nmol/l (cutoff with 100% SN) plus 1 mg DST O50 nmol/l had an 88.9% SN and an 85.2% SP (similar to SH criterion at enrollment). Conclusions: In AI patients, LNSalC measured by LC-MS/MS appears to be useful in combination with 1 mg DST for diagnosing SH, while it is not useful as a single criterion.