The first synthesis of the tetrasaccharide
fragment of the anthracycline
natural product Arugomycin is described. A reagent controlled dehydrative
glycosylation method involving cyclopropenium activation was utilized
to synthesize the α-linkages with complete anomeric selectivity.
The synthesis was completed in 20 total steps, and in 2.5% overall
yield with a longest linear sequence of 15 steps.
Polycyclic aromatic hydrocarbons (PAHs) are important compounds in materials chemistry, particularly for optoelectronic applications. One strategy for tuning PAH properties involves the net exchange of carbon atoms for heteroatoms, such...
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