CuFeSe2 nanomaterial with high thermal conversion efficiency, well superparamagnetism, effective x-ray attenuation ability, multifunctional groups and excellent biocompatibility is beneficial to the construction of multimodal imaging probes which can combine various imaging modes to provide a synergistic advantage over a single imaging mode. This study aimed to develop a novel multimodal nanocontrast agent CuFeSe2@diethylenetriaminepentaacetic acid (DTPA)-Gd to obtain imaging information with high specificity, high sensitivity and high contrast. The morphology and physical characteristics of CuFeSe2@DTPA-Gd were detected by transmission electron microscope, scanning electron microscope, x-ray single crystal diffraction, vibrating sample magnetometer and fourier transform infrared spectrometer. The toxicity of CuFeSe2@DTPA-Gd in vivo was evaluated by hematoxylin-eosin staining. The imaging capability of CuFeSe2@DTPA-Gd in vitro and in vivo was evaluated by magnetic resonance imaging (MRI) and computed tomography (CT). This study successfully prepared nanoparticles CuFeSe2@DTPA-Gd, and experimental results in this study demonstrated CuFeSe2@DTPA-Gd is expected to be a useful CT and MRI T1-weighted imaging/T2-weighted imaging three-modal contrast agent in clinic.
Objective:
While liver biopsy is the golden standard for liver-fibrosis diagnosis, it’s also invasive and has many
limitations. Non-invasive techniques such as magnetic resonance imaging (MRI) need to be further developed for liver
fibrosis staging. This study aimed to evaluate the diagnostic accuracy of gadolinium ethoxybenzyl diethylenetriamine
penta-acetic acid (Gd-EOB-DTPA)-enhanced MRI for liver fibrosis through systematic review and meta-analysis.
Methods:
This study comprehensively searched relevant article in PubMed, Embase, and the Cochrane Library published
from 2004 to 2018 to find studies analyzing the diagnostic accuracy of Gd-EOB-DTPA-enhanced MRI for liver fibrosis.
Two reviewers independently screened the retrieved articles, extracted the required data from the included studies, and
evaluated the methodological quality of the studies. The pooled sensitivity, specificity, positive likelihood ratio, negative
likelihood ratio, diagnostic odds ratio, and summary receiver operating characteristics (SROC) curve were assessed.
Results:
This study finally included 16 studies (n = 1,599) and selected a random-effects model based on the results of the
I
2 statistic to combine them. The areas under the SROC curve for the detection of F1 or greater, F2 or greater, F3 or
greater, or F4 liver fibrosis were 0.8669, 0.8399, 0.8481, and 0.8858, respectively.
Conclusion:
Gd-EOB-DTPA-enhanced MRI showed a good diagnostic performance for staging liver fibrosis, especially
for F4 liver fibrosis.
As a convenient and non-invasive diagnostic method, computed tomography (CT) has been developing continuously, and dual-energy CT imaging is one of its current research hotspots. Dual-energy CT, using two different X-ray energies for imaging, can generate spectral image sets such as virtual monoenergetic images, virtual non-contrast images, iodine density images, uric acid images, calcium inhibition images, and effective atomic number images. These images could help to increase the contrast of vascular, improve the detection rate of lesions, reduce artifacts, reduce the dose of radiation, and characterize materials. Dual-layer spectral detector CT, a detector-based dual-energy scanning device, has an X-ray tube and a dual-layer X-ray detector that can simultaneously separate low-energy and high-energy photons from a multi-energy X-ray beam, which means excellent time registration. This paper aims to introduce the applications of dual-layer spectral detector CT in abdominal angiography, including optimizing image quality, reducing the dose of contrast agent and radiation, providing richer diagnostic information, organ perfusion, and thrombus identification.
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