A series of new water‐soluble cyclopalladated ferrocenylimines were designed and prepared. They were efficient catalyst for Suzuki coupling reactions of aryl bromides and phenylboronic acid in neat water under ambient atmosphere. Among of these catalysts, the catalyst (C2D) could be reused for 6 times for the Suzuki coupling reaction of 4‐bromotoluene with phenylboronic acid in EtOH/H2O under ambient atmosphere, in which no significant loss activity of C2D was observed.
SummaryA highly efficient synthesis of enantiomerically pure (S) and (R)-isomers of N-(2,3-dihydroxypropyl)arylamides has been developed with good overall yields in a two step process. The key step involves the ring opening of the chiral epoxide with a nitrogen heterocyclic carbene (NHC) and further rearrangement to chiral N-(2,3-dihydroxypropyl)arylamides in high yields and enantioselectivity. During the reaction, no erosion in chiral purity was observed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.