Three cases of SCt't'rt' bronchospasm occurring ill knowll asthmatics follQ[cill{; the admillistration of enflurancc are described. Other commonly known causes of bronchospasm did not seem to be operative. J10derate(v high concentrations of halothane in the respired gases protected against the bronchospasm whereas a moderately high blood concentration did not. Although the authors have administered enflurane to other known asthmatics u;ithout producillf!, bronchospasm, they feel it should be lIsed with caution in such patients.
The metabolism of enflltrane, used as a supplement to muscle relaxant and nitrous oxide anaesthesia, was studied in 19 healthy adult male surgical patients; seven control patients received halothane. Patients receiving enflurane were randomly allocated to three groups: Group I-~ JIAC for t hour (dosage=t MAC hOltr) Group II-~ JIAC for 2 hours (dosage=l ..JIAC hOltr) Group III-} JIAC for 4 holtrs (dosage=2 MAC hours) AI etabolism of enflurane to inorganic fluoride (F-) was indica~ed by elc'L'ated serum Fconcentration and elevated Itrinary excretion of F-. Peak scrum Fconcentration was measured in samples collected immediately at the end of enjlurane anaesthesia and fell thereafter,
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