A small portion of lesions are refractory to coronary angioplasty even when very high pressures are used. This leads to a failed angioplasty and emergent bypass surgery. We successfully attempted the technique of hugging balloons or two polyethelene terephthalate (PET) balloons inflated simultaneously side by side which successfully dilated a lesion which would not dilate using standard techniques. This technique successfully dilated the lesion as the geometry of two balloons inflated side by side is different from one balloon. Two balloons inflated side by side consists of two outer semi-circles and a central trapezoidal square area. This altered geometric configuration may be important in successfully dilating a lesion refractory to standard dilating techniques. Higher pressures can be attained with smaller balloons as the burst pressure is higher in smaller balloons compared to larger balloons.
BackgroundSignificantly reduced plasma 24OHC was found in HD patients compared with healthy subjects. The reduction of plasma 24OHC parallelled the shrinking of caudate volumes at MRI, suggesting that the observed reduction of plasma 24OHC might reflect the progressive loss of metabolically active neurons in the grey matter. In a small group of prodromal subjects, plasma concentration of 24OHC was similar to controls. However, the subjects closer to motor onset and with smaller striatum presented lower levels of 24OHC, similar to the concentrations of the HD patients (Leoni et al, 2008).MethodsBy isotope dilution Mass Spectrometry we measured plasma 24OHC in 30 Controls individuals, 90 pre manifest gene positive for HD individuals (Far from Onset (Far, n=21), mid term form onset (Mid, n=36), Near to Onset (Near, n=33), and in 30 gene clinically manifesting individuals (manifest HD) from the PREDICT-HD project.ResultsThe levels of 24OHC in plasma were significantly reduced in the clinically manifest patients compared to Controls (ANOVA, p<0.001) and compared to the Far group (p<0.001). No significant differences were found between Near and manifest individuals, as well no significant differences were found between Controls and Far individuals. Both Controls and Far from onset groups were significantly higher compared to Near individuals (<0.001). The individuals described as Mid have slightly but not significantly lower levels compared to Controls and Far from onset individuals, while higher compared to Near to onset (NS) and clinically manifest individuals (0.003). Levels of 24OHC were significantly correlated to disease burden with a significant trend towards reduction along the progression of the disease. Statistically significant correlations were also found between plasma 24OHC and MRI, and 24OHC selected and functional, motorial and psychological parameters.
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