The gold(rr1) complex [Au(O,CMe),(dmamp)] [dmamp = 2-(dimethylaminomethyl)phenyl] is hydrolysed in wholly or partially aqueous solution. One acetate ligand, presumed to be that trans to the Au-C bond, exchanged with a water molecule rapidly on the NMR time-scale. At high concentrations of water a further hydrolysis step was also discernible, which involved the second acetate group while, in aged solutions, small amounts of a third species, possibly the second isomer of [Au(O,CMe)(dmamp)(H,O)] +, was formed. The reaction of aqueous or dimethyl sulfoxide solutions of the gold(m) complex with various biological ligands was followed by NMR spectroscopy and a range of reactivities was found: caffeine and adenosine showed no reaction, L-cysteine, glutathione and adenine reacted quantitatively and guanosine and inosine showed partial reaction. In in vilro biological tests for antibacterial activity, [Au(O,CMe),(dmamp)] exhibited a potentially useful selectivity .We have reported on the antibacterial and antitumour activity of [AuCl,(dmamp)] 1 [dmamp = 2-(dimethylaminomethy1)phenyl] which showed some activity analogous to that of cisplatin.' The antibacterial selectivity was not high, and the application of this gold complex is inhibited by its negligible solubility in water. We have therefore sought a water-soluble derivative and the diacetato analogue 2 has proved very suitable. Initial studies suggested that it underwent ready hydrolysis, and we have now made a detailed study of this process in water and in mixed solvents. Since the complex shows interesting biological behaviour, some of which is summarised here, we have also examined its reactions with model biological molecules.
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