OBJECTIVES To understand the natural history of frailty after an aggressive surgical intervention, kidney transplantation (KT). DESIGN Prospective cohort study (December 2008–March 2014). SETTING Baltimore, Maryland. PARTICIPANTS Kidney transplantation recipients (N = 349). MEASUREMENTS The Fried frailty score was measured at the time of KT and during routine clinical follow-up. Using a Cox proportional hazards model, factors associated with improvements in frailty score after KT were identified. Using a longitudinal analysis, predictors of frailty score changes after KT were identified using a multilevel mixed-effects Poisson model. RESULTS At KT, 19.8% of recipients were frail; 1 month after KT, 33.3% were frail; at 2 months, 27.7% were frail; and at 3 months, 17.2% were frail. On average, frailty scores had worsened by 1 month (mean change 0.4, P < .001), returned to baseline by 2 months (mean change 0.2, P = .07), and improved by 3 months (mean change −0.3, P = .04) after KT. The only recipient or transplant factor associated with improvement in frailty score after KT was pre-KT frailty (hazard ratio = 2.55, 95% confidence interval (CI) = 1.71–3.82, P < .001). Pre-KT frailty status (relative risk (RR) = 1.49, 95% CI = 1.29–1.72, P < .001), recipient diabetes mellitus (RR = 1.26, 95% CI = 1.08–1.46, P = .003), and delayed graft function (RR = 1.22, 95% CI = 1.04–1.43, P = .02) were independently associated with long-term changes in frailty score. CONCLUSION After KT, in adult recipients of all ages, frailty initially worsens but then improves by 3 months. Although KT recipients who were frail at KT had higher frailty scores over the long term, they were most likely to show improvements in their physiological reserve after KT, supporting the transplantation in these individuals and suggesting that pretransplant frailty is not an irreversible state of low physiological reserve.

Anhydrous iron dibromide complexes bearing bidentate α-diimine ligands Ar N=C(Me)-(Me)C=N Ar and Ar BIAN (BIAN = bis(imino)acenaphthene; Ar = dpp and Mes; dpp = 2,6diisopropylphenyl; Mes = 2,4,6-trimethylphenyl) have been prepared and characterized by 1 H NMR spectroscopy. The aryl-substituted BIAN complexes were structurally characterized by single-crystal X-ray diffraction, and their metrical parameters are consistent with a redoxinnocent chelating ligand. A high-spin iron(II) electronic structure description for the Ar BIAN iron complexes is supported by Mössbauer spectroscopy, solution state magnetic measurements, and quantum-chemical calculations. Upon reduction, the iron complexes promote catalytic hydrosilylation of 1-hexene with phenylsilane at 22 o C.

BackgroundThoracic endovascular aortic repair (TEVAR) has become the standard of care for thoracic aortic aneurysms and increasingly for blunt thoracic aortic injury (BTAI). Postoperative complications, including spinal cord ischemia and paraplegia, have been shown to be less common with elective TEVAR than with open thoracic or thoracoabdominal repair. Although small cohort studies exist, the postoperative complications of endovascular repair of traumatic aortic injury have not been described through large data set analysis.MethodsA retrospective cohort analysis was performed of the American College of Surgeons Trauma Quality Improvement Program registry spanning from 2007 to 2017. All patients with BTAI who underwent TEVAR, as indicated by the Abbreviated Injury Scale or the International Classification of Diseases (ICD-9 or ICD-10), were included. Categorical data were presented as proportions and continuous data as mean and SD. OR was calculated for each postoperative complication.Results2990 patients were identified as having undergone TEVAR for BTAI. The postoperative incidence of stroke was 2.8% (83), and 4.7% (140) of patients suffered acute kidney injury or renal failure. The incidence of spinal cord ischemia was 1.9% (58), whereas 0.2% (7) of patients suffered complete paraplegia. Renal events and stroke were found to occur significantly more frequently in those undergoing TEVAR (OR 1.758, 1.449–2.134 and OR 2.489, 1.917–3.232, respectively). Notably, there was no difference between TEVAR and non-operative BTAI incidences of spinal cord ischemia or paraplegia (OR 1.061, 0.799–1.409 and OR 1.698, 0.728–3.961, respectively).DiscussionPostoperative intensive care unit care of patients after BTAI has historically focused on awareness of spinal cord ischemia. Our analysis suggests that after endovascular repair of blunt aortic trauma, care should involve vigilance primarily against postoperative cerebrovascular and renal events. Further study is warranted to develop guidelines for the intensivist managing patients after TEVAR for BTAI.Level of evidenceLevel III.