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Elucidating protein rigidity offers insights about protein conformational changes. An understanding of protein motion can help speed drug development, and provide general insights into the dynamic behaviors of biomolecules. Existing rigidity analysis techniques employ fine-grained, all-atom modeling, which has a costly run-time, particularly for proteins made up of more than 500 residues. In this work, we introduce coarse-grained rigidity analysis, and showcase that it provides flexibility information about a protein that is similar in accuracy to an all-atom modeling approach. We assess the accuracy of the coarse-grained method relative to an all-atom approach via a comparison metric that reasons about the largest rigid clusters of the two methods. The apparent symmetry between the all-atom and coarse-grained methods yields very similar results, but the coarse-grained method routinely exhibits 40% reduced run-times. The CGRAP web server outputs rigid cluster information, and provides data visualization capabilities, including a interactive protein visualizer.

Background  A healthy public sphere requires a flow of reliable, trustworthy, and accurate information. Scholarly research is one such source but, to be most effective, it must reach the public. One possible dissemination route for that material is political pundits. Analysis  We extracted the tweets of thirty-two Canadian pundits with links to scholarly research and studied the main motivations for sharing a link to a scholarly article. Conclusion and implications  We found that most pundits we studied tweeted at least one link to a scholarly article and that the motivations for sharing varied. However, our sample shared links to scholarly journal articles infrequently. Résumé Contexte  Pour bien fonctionner, une sphère publique requiert un flux d’informations qui soient fiables, dignes de confiance et précises. La recherche savante est une source de telles informations, mais pour être efficace elle doit rejoindre le public. Une façon de disséminer la recherche consiste à recourir à des commentateurs politiques. Analyse  Nous avons passé en revue les gazouillis de 32 commentateurs canadiens ayant des liens avec la recherche savante et nous avons étudié leurs motivations principales pour partager un lien vers un article savant. Conclusion et implications  Nous avons découvert que la plupart des commentateurs de notre échantillon ont inclus au moins un lien vers un article savant dans leurs gazouillis et que leurs motivations pour le faire étaient diverses. Cependant, ces commentateurs ne partageaient pas souvent des liens vers des articles paraissant dansdes revues savantes.

Tian yu di 天與地 (When Heaven Burns, 2011), a primetime television series that was screened in Hong Kong from November 2011 to January 2012, tells the story of a young rock band struggling with the memory of having eaten a fellow bandmate in order to survive a mountaineering accident. Cannibalism not only bewildered the mainstream TV audience, but it was also viewed as an allusion to the June Fourth crackdown on the Tiananmen student movement. This essay explores cannibalism as a method that questions the assimilation of Hong Kong into the national body politic of China. Its argument is twofold. First, cannibalism in this drama disrupts the bourgeois consciousness of a healthy subject, exploring a shattered but renewed life that questions the dissolution of food in the making of a healthy subject. Second, by challenging the bourgeois model of a reconciled body, this drama series throws critical light on Hong Kong's coerced “swallowing” of a China excessive in its material aggrandizement, restoring the power of imagination of possible futures not dictated by Hong Kong's increasing integration with China. Finally, this essay suggests that cannibalism, viewed through the Tiananmen legacy, may function as a method to explore modes of relationality between Hong Kong and Mainland China.

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