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Dr Jacobs had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

The American Medical Association 1 and National Academies of Sciences, Engineering, and Medicine 2 have emphasized the importance of appropriately distinguishing between sex and gender in research and medicine. Many US federal and state databases supply the US Congress, state leadership, and academic researchers with information upon which policies are developed. Therefore, ensuring that sex and gender are characterized appropriately in these databases is fundamental to population health and policy guidelines. We investigated whether databases use these terms in accordance with current recommendations and represent the intended individual demographic variable(s) collected.Methods | This cross-sectional study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. The study was exempt from institutional review board approval because all data were publicly available, and it did not involve patient or protected information. Two authors (J.W.J. and L.A.B.) assessed 75 databases, reports, and surveys (eTable in the Supplement) published by US federal, state, and local entities via the US government's open-data website. 3 Analysis was limited to 3395 databases containing a gender and/or sex variable and 512 databases that explicitly stated the variable(s) queried and options or responses reported. Of these databases, 10% were selected using a randomization method in Microsoft Excel with additional oversampling of national health-related databases. The terms gender and sex were evaluated to determine appropriate use.The American Medical Association 1 defines sex on the basis of biological differences, including reproductive anatomy

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Erythromelalgia is a neurovascular disorder which causes pain, swelling, erythema, and warmth of the distal extremities. Primary disease is due to a genetic mutation in the SCN9A gene, but secondary erythromelalgia can be the consequence of a variety of underlying etiologies, including drug and toxin exposures. The disease is rare, occurring in only 1.3 out of every 100,000 in the United States, and symptoms can vary significantly in severity and presentation. Therefore, it can be difficult to recognize the disorder, identify the source, and promptly treat the condition. We report a reversible cause of erythromelalgia induced by the use of oral cyclosporine. This correlation is poorly documented in literature, with limited accounts identifying an association between erythromelalgia and cyclosporine. As drug-induced erythromelalgia represents a reversible cause of disease, physicians should obtain a detailed medication history during the diagnostic workup, specifically inquiring about the use of cyclosporine.

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