Anecdotal evidence suggests the possible association of psychiatric disorders with Mӧbius sequence, although the evidence is not conclusive. Intermittent presentation of auto-aggressive outbursts, in particular, could be related to Mӧbius sequence, different from the common psychotic symptoms. The present report describes the clinical case of a young man with Mӧbius syndrome who exhibited a complex representation of severe mental retardation and concomitant psychiatric disorders. Extremely rare psychiatric disorders represented the main feature in this clinical case, besides the other well-known signs and symptoms of the Mӧbius syndrome. Psychiatric disorders could, therefore, prove to be an interesting field of study for an extensive exploration of the Mӧbius syndrome.
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