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Uma série de novas Bases de Mannich (HL1-HL13) derivadas da 2-hidroxi-1,4-naftoquinona (lausona), benzaldeídos substituídos [C 6 = Bu) were determined by single crystal X-ray diffraction studies. All complexes crystallize in centrosymmetric space groups, with a copper atom in the inversion centre. Two L − coordinate through the naphthalen-2-olate oxygen and secondary amine-N atoms, forming sixmembered chelate rings around the copper atom in a trans-N 2 O 2 environment; spectroscopic data confirm that the other complexes exhibit similar molecular arrangement. The antimicrobial activity of all compounds has been tested on seven different strains of bacteria: Bacillus cereus, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. In general, Mannich bases were more active than complexes, HL11 (R 1 = OH; R 2 =H; R 3 = Me; R 4 = Bn) and HL13 (R 1 = OH; R 2 = H; R 3 = Br; R 4 = Bn) being the most potent inhibitors. The MIC for the most active compound HL11 against S. Coli was 20 µmol L -1 (8 µg mL ) and well below most values reported for other naphthoquinones.

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