This study describes a satisfactory technique for construction of TMA from a gross tumour specimen. Such a technique is well suited to centres which handle a high number of cases of a particular type, such as breast carcinoma. Further studies on other tumour types would help in validating these results.
In conclusion, the molecular phenotype in DCIS correlates well with that of coexisting IDC, suggesting that DCIS is a precursor lesion in these tumors. This correlation of molecular phenotype can be utilized in prediction of phenotype of the invasive component in a case with in-situ carcinoma.
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