Triple-negative breast cancer (TNBC) is a malignancy with high metastasis rate and poor prognosis. Limited drugs are effective for the treatment of TNBC patients.Ubiquitin specific proteases (USPs) are important posttranscription modulators that promote protein stability by reducing the ubiquitination of the proteins. Aberrant expression of USPs is involved in the development of numerous cancers. However, it remains poorly understood on the role of USP46 in TNBC growth and metastasis. In this study, we explored the clinical relevance, function and molecular mechanisms of USP46 in TNBC. USP46 expression was increased in breast cancer tissues. High expression of USP46 was associated with the poorer prognosis of the patients.Overexpression and knockdown experiments demonstrated that USP46 was critical for TNBC cell growth, migration, and tumorigenesis. Mechanistically, USP46 enhanced the protein stability of phosphoglycerate mutase 1 (PGAM1) via direct interaction. Importantly, USP46 stimulated the glycolysis and promoted the malignant growth of TNBC cells through upregulation of PGAM1. Our study reveals that USP46/PGAM1 axis contributes to TNBC progression and is a potential target for the treatment of TNBC patients.
Review question / Objective: Is Xiaochaihu decoction effective and safe in adjuvant chemotherapy treatment of breast cancer? Rationale: Breast cancer(BRCA) is a malignant tumor occurring in the lobular and ductal epithelium of the breast , which ranked first among female malignant tumors , and mainly concentrated in women aged 40 to 60 years. BRCA is a INPLASY 1
Review question / Objective: Is Chaihu Shugan Powder plus or minus combined with chemotherapy effective and safe in adjuvant treatment of breast cancer? Rationale: Breast cancer(BRCA) ranks the first among female malignancies. At present, there are about 1.7 million new cases of breast cancer in the world every year, more than 52% of the cases and 62% of the deaths of breast cancer patients occur in some countries of lower income and middle class respectively, posing a INPLASY 1
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