Oncolytic viruses (OVs), including oncolytic herpes simplex viruses (oHSVs), are promising therapeutics against cancer. Here, we report two ICP6-mutated HSVs (type I) generated by CRISPR/Cas9, rHSV1/ΔRR (with ICP6 ribonucleotide reductase[RR] domain deleted) and rHSV1/ΔICP6 (with a complete deletion of ICP6),
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