In this paper, a visible-light-promoted
cross-coupling of 4-alkyl-1,4-dihydropyridines
with thio-/selenium sulfonates under transition-metal-free conditions
is described. This strategy features easily available substrates,
mild reaction conditions, high yields, and high chemoselectivity.
A novel synthetic route for the construction of a sulfide or selenide
Csp3–S or Csp3–Se bond under transition-metal-free
conditions without an additive oxidant or base is developed. This
method is well extended to the synthesis of a class of thiolated or
selenylated glycosides that has not been explored before. Sulfoxides
were also successfully chemoselectively observed via a facile variation
of the atmosphere under photocatalyzed conditions.
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