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The synthesis and crystal structures of [Pb(Hssal)(2,2'-bipy)(DMF)]n (1), [Pb(Hssal)(2,2'-bipy)(H2O)]n (2), [Pb(Hssal)(phen)(DMF)]n (3), and [Pb3(ssal)2(phen)3]n (4) were reported, where Hssal2- and ssal3- are doubly and fully deprotonated 5-sulfosalicylates, 2,2'-bipy is 2,2'-bipyridine, and phen is 1,10-phenanthroline. Compounds 1-4 were synthesized by the various reaction conditions, such as reaction temperature, molar ratio, and pH, and these structures are formed by infinite chains or layers where Pb(II) ions are linked by Hssal2- or ssal3- bridges. Compound 1, which has a ladderlike chain, was formed in DMF/H2O. Compound 2 with a H2O molecule coordinated to Pb(II) was prepared by a hydrothermal reaction. Compounds 3 and 4 were synthesized in a higher pH compared to compounds 1 and 2, containing the 2,2'-bipy ligand. In 1-3, 5-sulfosalicylates are doubly deprotonated, whereas in 4, 5-sulfosalicylate is fully deprotonated. Coordination modes of Hssal2- and ssal3- ligands in 1-4 are novel and are first reported in this presentation. Although compounds 1 and 3 have the same structural topology, their aromatic-aromatic interactions are significantly different. The coordination spheres of Pb(II) ions in 1 and 3 are holodirected, whereas in 2 and 4, they feature somewhat hemidirected properties with small holes or gaps. Compound 4 exhibits some interesting features that (1) there is not any solvent in the structure, (2) there are extensively aromatic-aromatic stacking interactions among aromatic rings, and (3) there is also a weak interaction between Pb(II) atoms in the trinuclear motif.

Introduction There is growing interest worldwide in the evaluation of positive mental health and wellbeing. Aim This study was to translate the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) into Chinese and assess the reliability and validity of this scale in a sample of undergraduate nursing trainees. Methods A forward and backward translation protocol was used to translate the scale into Chinese. The psychometric properties of the C-WEMWBS, such as internal consistency reliability, test-retest reliability and factorial validity, were analysed. Results All 14 items of the initial C-WEMWBS were rated as conceptually equivalent to those of the original version. Confirmatory factor analysis indicated the emergence of a single factor. The psychometric properties of the C-WEMWBS were satisfactory, with an internal consistency reliability of .94 and a test-retest reliability of .83. The item-total correlations ranged from .66 to .83. There was a moderate relationship (r = .52) between the C-WEMWBS and the WHO-5. Implications for practice This was the first Chinese version of the WEMWBS to be developed and psychometrically assessed with a sample of undergraduate nursing trainees. It provides a reliable quantitative tool to evaluate mental well-being in non-clinical settings, which has important implications for mental health nursing.

Activation of α7 nicotinic acetylcholine receptor on MCs is a mechanism by which nicotine enhances atherosclerosis.

The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex with ciprofloxacin (cpf), has been investigated. The complex crystallizes in the triclinic system, space group P-1. The cell dimensions are: a=6.874(2) Å, b= 10.761(3) Å, c= 17.969(5) Å, α=80.071(6)°, β= 85.253(6)°, γ=79.109(6)°，V=1284.5(6) Å3, and Z=2. The Cu (II) ion displays a five-coordinate square pyramidal coordination with two nitrogen donors from bpy, the 4-keto and 3-carboxylate oxygen donors of cip, and the third nitrogen atom of the pip anion occupying the fifth site. There is a stack effect between cip ring and bpy ring from another molecule, where the stacking distance is about 3.5 Å. The results of elemental analysis and FT-IR measurement are also included. Both ligand and complex were assayed against gram-positive and gram-negative bacteria by the doubling dilutions method. The complex shows the same minimal inhibitory concentration (MIC) against S. Aureus and E. Coli bacteria as the corresponding ligand.

SignificanceReactive oxygen species (ROS) generation due to electron leak from the mitochondria may be involved in physiological or pathological processes. NDUFA13 is an accessory subunit of mitochondria complex I with a unique molecular structure and is located close to FeS clusters with low electrochemical potentials. Here, we generated cardiac-specific conditional NDUFA13 heterozygous knockout mice. At the basal state, a moderate down-regulation of NDUFA13 created a leak within complex I, resulting in a mild increase in cytoplasm localized H2O2, but not superoxide. The resultant ROS served as a second messenger and was responsible for the STAT3 dimerization and, hence, the activation of antiapoptotic signaling, which eventually significantly suppressed the superoxide burst and decreased the infarct size during the ischemia-reperfusion process.

Four structurally diverse complexes, {[Pb(Hssal)(2,2′-bipy)](4,4′-bipy) 0.5 } n (1), [Pb 2 (Hssal) 2 (2,2′-bipy) 2 (4,4′-bipy)-(H 2 O) 2 ] (2), [Pb(Hssal)(phen)(4,4′-bipy) 0.5 ] n (3), and [Pb(Hssal)(2,2′-bipy)(bpe) 0.5 ] n (4), have been synthesized and characterized by elemental analyses, IR, thermogravimetric analyses, fluorescent spectra, and single-crystal X-ray analyses, where Hssal 2is doubly deprotonated 5-sulfosalicylate, 2,2′-bipy is 2,2′-bipyridine, phen is 1,10phenanthroline, 4,4′-bipy is 4,4′-bipyridine, and bpe is trans-1,2-bis(4-pyridyl)ethylene. The structure of complex 1 possesses a one-dimensional ladderlike chain with guest 4,4′-bipy molecules, while the molecular structure of complex 2 is a dimeric species with a coordinating 4,4′-bipy ligand. Complex 3 consists of a one-dimensional ladderlike chain with monodentate 4,4′-bipyridine but somewhat different from that of complex 1. Complex 4 is a two-dimensional layer structure. In 1−4, all 5-sulfosalicylates are doubly deprotonated, and all carboxylate groups of Hssal 2chelate to Pb II ions; however, the coordination modes of sulfonyl groups are different: syn−syn bridging in 1, noncoordinating in 2, syn-skew bridging in 3, and one-atom bridging in 4. The noncoordinating mode of sulfonate in Pb II complexes containing 5-sulfosalicylate is first reported in this presentation. The 4,4′-bipy ligands act as guest molecules in 1, dimeric linkers in 2, and monodentates in 3. The π−π stacking interactions can be observed in complexes 1−3, whereas there is no such interaction in complex 4. The coordination spheres of Pb II ions in 1−4 are controlled by three factors: the activity of a lone pair of electrons, weak Pb−O interactions, and π−π stacking interactions. The Pb II lone pair in 4 is inactive, whereas in 1−3, they are stereochemically active. The thermal stability and fluorescent property of complexes 1−4 are different from those of Pb II complexes only containing chelating ligands, [Pb(Hssal)(2,2′-bipy)(DMF)] n (5), and [Pb(Hssal)(2,2′-bipy)(H 2 O)] n (6), and [Pb(Hssal)-(phen)(DMF)] n (7).

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