The increasing of online coronavirus disease-2019 (COVID-19) information-sharing in digital media can contribute to the emergence of misinformation in public. Much insufficient knowledge will confuse public understanding and affect their quality of life. The study purposed to assess the knowledge and its influence on Indonesian students' quality of life during the COVID-19 crisis. A cross-sectional study was conducted between October and December 2020 by distributing online questionnaires. The data analysis was run through the Spearman correlation method by using SPSS version 21.0. A total of 200 respondents aged over 17 years were recruited using a snowball sampling technique. Most study respondents had insufficient knowledge about COVID-19, 23% of them had moderate knowledge, and only 17.5% had high knowledge. They obtained primary sources of COVID-19 information from social media platforms. The results showed that health science students have a better understanding than social science students (ρ<em>&lt;</em>0.001). The level of knowledge has a significant associated with psychological domain (ρ=0.020), environmental domain (ρ=0.046), and overall quality of life (ρ=0.047). Thus, the media control center is vital to encounter valid information in providing better knowledge and quality of life during a pandemic.

Novel coronavirus was first identified in China in December 2019, causing several cases of the new type of pneumonia. The exported cases were found in other countries, including countries in the Southeast Asia region. At the same time, no cases were confirmed in Indonesia. We aimed to assess COVID-19 related knowledge, precautionary actions, and perceived risk among general Indonesian population when there were no confirmed cases in Indonesia. This study was a descriptive cross-sectional study involving 382 participants aged 17 years and above residing in Indonesia. The data was collected through the online questionnaire from February 19^thto February 29^th 2020. The average score of COVID-19 related knowledge was 88.0%, whereas 83.8% of the participants had a high level of knowledge. The average score of taking precautionary actions was 77.4% and 65.7% had a high level of performance. In terms of the perceived risk of COVID-19, only 11.3% of the participants perceived themselves likely to acquire COVID-19 when compared with other diseases or accidents. The perceived risk of COVID-19 was significantly associated with precautionary action (p&lt;0.05). Perceived risk of COVID-19 was at a low level when there were no confirmed cases. Effective strategies of risk communication are needed to improve precautionary actions to prevent COVID-19.

Indonesia confirmed its first coronavirus disease 19 (COVID-19) case on 2nd March 2020, when other countries have already reported several numbers in the previous month. This study aimed to explore the risk perception of Indonesians in the early stage of the COVID-19 outbreak. This cross-sectional study was conducted among 495 participants using a web-based questionnaire. Primary data were collected from 3rd to 27th March 2020 including the perceived severity, vulnerability, threat, self, and response efficacy of the participants. The results showed that the perceived threat of the outbreak in its early stage is the second highest compared to other diseases. The perceived severity among the participants was high. However, they had a low vulnerability. Those in the middle region showed a higher level of self and response efficacy. Meanwhile, people who work as private sector employee (β=0.146, p=0.004), live in the western region (β=-0.184, p=0.000), with a higher knowledge score (β=0.096, p=0.032) had a higher perceived threat. These results found those who had high knowledge, was also had higher perceived risk. The most important of these studies have determined various factors related to risk perception, thus it could be good preliminary evidence for public health authorities to arrange an effective way for epidemic control.

Background:: The large interindividual variability in the genetic polymorphisms of sirolimus (SIR)-metabolizing enzymes, transporters, and receptors can lead to qualitatively and quantitatively distinct its therapeutic responses. Objective:: We examined the impact of numerous candidate single-nucleotide polymorphisms (SNPs) involved in the trough concentration of SIR-based immunosuppressant regimen. Method:: This was a retrospective long-term cohort study involving 69 renal allograft recipients. Total DNA was isolated from recipient blood samples and trough SIR concentrations were measured by microparticle enzyme immunoassay. Genome sequence reading was targeted based on next-generation sequencing. The association of tagger SNPs to SIR trough concentrations with non-genetic covariate adjusting was analyzed using logistic regression. Results:: A total of 300 SNPs were genotyped in the recipient DNA samples using target sequencing analysis. Only the SNP of CYP3A4 (Ch7: 99361466 C> T, rs2242480) had a significantly higher association with SIR trough concentration as compared to the other 36 tagger SNPs. The mean trough SIR concentration of patients in the CYP3A4 rs2242480-CC group was more significant compared to that of the CYP3A4 rs2242480-TC and TT group, respectively 533.3; 157.4 and 142.5 (ng/ml)/mg/kg, P<0.0001. After adjusting the SNPs, there was no significant association between clinical factors such as age, follow-up period, incidence of delayed graft function, immunosuppression protocol, and sex with SIR trough concentration. Conclusion:: These findings indicated the significant association of polymorphism in the CYP3A4 (Ch7: 99361466 C> T, rs2242480) with SIR trough concentration after 1-year administration in patients who have undergone kidney transplantation.