Aim: To re-audit the practice of CT guided lung biopsies Standard: British Thoracic Society guidelines Methods: The present audit of CT guided lung biopsies has been undertaken to assess if changes in practice instituted following an initial audit in 2003/2004 has improved the diagnostic yield and impacted on the complication rate.Results: 97 biopsies were carried out in 90 patients. The overall diagnostic rate was 85.6 % (66 true positive and 17 true negatives). There were 14 (14.4%) false negatives. 28 (28.9%) patients developed a pneumothorax and 6 patients (6.2%) required insertion of chest drain.Conclusion: The overall diagnostic rate is within the BTS standard and is higher than the previous audit (85.6 % compared to 81 % in the previous audit). The number of biopsies performed has increased significantly. The complication rate for pneumothorax is higher than the BTS standard. The technique of biopsy has also changed with most biopsies now being core biopsies rather than fine needle aspiration (FNA).
PTH-106 Figure 3 Conclusions Plasma S100A8/A9 is significantly elevated in ACLF, correlating strongly with activation of pro-inflammatory mediators and indices of disease severity, extra-hepatic organ failure and outcome. Our in vitro data indicate that this mediator promotes inflammation and represents a novel therapeutic target in ACLF.
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