Fibroblasts from patients with active NFD are either activated to synthesize elevated levels of HA or contain another cell type, possibly derived from circulating fibrocytes. In both disorders, there is additionally a serum-derived factor that stimulates production of sulphated GAGs and HA by fibroblasts.
And if you say, "Why should we trouble with these relics and with all this past history?" then I will say that in order to understand the correct functioning of the nervous system and its pathology, we need to know the evolutionary and embryological processes that have made it what it is. How else should we expect to learn how to control and heal it?1 WESTERN encephalitis (WE) virus has special proclivity for the nervous systems of infants. Between 25% and 30% of all cases of WE occur in infants less than 1 year of age.2 Furthermore, sequelae are much more frequent and more severe When the illness occurs in infancy than when it occurs in older persons.3-5 A recent analysis of findings of the California Encephalitis Clinical Follow-Up Study, which is now in its second decade, showed that 79% of 29 children who had WE before the age of 1 month had sequelae and the sequelae in 50% were severe. In contrast, among the 14 children who became ill between the ages of 36 and 47 months, only 21% had sequelae and in all cases the sequelae were mild.Incidence and severity decreased rapidly as age at onset increased. The highest inci¬ dence and greatest severity of sequelae oc¬ curred in infants who acquired the virus sometime between two weeks before and three months after birth. This time is re¬ ferred to here as the perinatal period.The sequelae of perinatal WE were found to vary in two important dimensions:First, sequelae varied according to type of impairment. Sequelae were of two major types: behavioral and cognitive. Behavioral sequelae included all types of motor (mus¬ cle) disorders from the most gross, such as quadriplegia, to the most subtle, such as dis¬ torted emotional expression, irritability, and impairment of writing or speech.6 Cog¬ nitive sequelae included disorders of per¬ ception, comprehension, memory, and rea¬ soning.Second, sequelae varied according to their time of appearance following the acute illness. The interval between the acute ill¬ ness and the appearance of sequelae varied widely; for convenience, sequelae were clas¬ sified into (1) those that continued without delay from the acute illness, and (2) those that appeared to be delayed, that is, those that arose after what appeared to be clinical recovery.These two characteristics of sequelae, (1) their type, behavioral and cognitive, and(2) their time of appearance following the acute illness, continuing and delayed, were closely related. Contnuing sequelae began as behavioral disorders with cognitive fea¬ tures arising later; delayed sequelae were
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