This work is supported in part by the Information Technology Industry Development Agency (ITIDA) under number ARP2019.R27.4.ABSTRACTA growing attention is given to exploiting Photoplethysmography (PPG) signals in noninvasively measuring many physiological vital signs. Many machine deep learning models were trained for predicting the continuous arterial blood pressure (ABP) or just the systolic and diastolic blood pressure (BP) values based on a public database. However, jointly cleaning the PPG-ABP dataset that is the most critical pre-processing step for training quality is still in need for more investigations. There is a considerable amount of anomaly data that has to be excluded before any training stage. This paper introduces a two-level joint PPG-ABP cleaning technique conducted at a signal level and per-beat level. Many quality metrics have been checked successively for excluding improper data. These metrics achieve a coarse cleaning step. Finally, principal component analysis (PCA) is exploited for fine cleaning the remaining data from the former stage. The cleaning efficiency is evaluated by measuring its impact on the deep-learning-based BP estimation models. The trained model based on our cleaned data shows performance enhancement in terms of prediction error and the correlation between the predicted and ground-truth BP. Segmented and cleaned PPG/ABP dataset will be publicly available at both signal level and beat level. Based on the simulation results, the proposed cleaning technique enhances the standard deviation of the prediction error of systolic and diastolic blood pressure by 11.68 % and 10.81 %, respectively. Also, it enhances the mean absolute error of the prediction of systolic and diastolic blood pressure by 14.79 % and 11.70 %, respectively.
Automated cell nuclei delineation in whole-slide imaging (WSI) is a fundamental step for many tasks like cancer cell recognition, cancer grading, and cancer subtype classification. Although numerous computational methods have been proposed for segmenting nuclei in WSI images based on image processing and deep learning, existing approaches face major challenges such as color variation due to the use of different stains, the various structures of cell nuclei, and the overlapping and clumped cell nuclei. To circumvent these challenges in this article, we propose an efficient and accurate cell nuclei segmentation method based on deep learning, in which a set of accurate individual cell nuclei segmentation models are developed to predict rough segmentation masks, and then a learnable aggregation network (LANet) is used to predict the final nuclei masks. Besides, we develop cell nuclei segmentation software (with a graphical user interface—GUI) that includes the proposed method and other deep-learning-based cell nuclei segmentation methods. A challenging WSI dataset collected from different centers and organs is used to demonstrate the efficiency of our method. The experimental results reveal that our method obtains a competitive performance compared to the existing approaches in terms of the aggregated Jaccard index (AJI=89.25%) and F1-score (F1=73.02%). The developed nuclei segmentation software can be downloaded from https://github.com/loaysh2010/Cell-Nuclei-Segmentation-GUI-Application.
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