Human exposure to genotoxic compounds present in ambient air has been sdied using selected biomarkers in nonsmoking Danish bus drivers and pol workers. A li n variadion in biomarker levels was observed. Significantly higher levels of bulky carcinogen-DNA adducts (75.42 adducts/108 nucleotides) and of 2-amino-apidic semialdehyde (AAS) in plasma proteins (56.7 pmollmg protein) were observed in bus drivers working in the central part of Copenhagen, Denmark In contrast, significantly higher levels of AAS in hemoglobin (55,8 pmollmg protn), malondialdeh in plasma (0.96 nol/m plasma) nd polycic aromatic hydrocarbon (PAH)-albumin adduct (3.38 finol/pg lbumin) were observed in the suburban group. The biomarker levels in postal workers were similar to the levels in suburban bus drivers. In the combined group of bus drivers and postal workers, negative corlations were observed between bulky carcinogen-DNA adduct and PAH-albumin levels (p -0.005), and between DNA adduct and .y-glutamyl semialdhyde (GGS)

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