The acetamido compound (1ÜU mg.) was dissolved in 1 ml. of 8 N ethanolic hydrogen chloride solution and allowed to remain at room temperature for sixteen hours. After evaporation of the alcohol, concentrated hydrochloric acid (0.25 ml.) was added to the residue and the solution evaporated on a steam-bath. The 2-amino-4-ethylthiazole hydrochloride was recrystallized from a mixture of ethanol and acetone; m. p. 185-187°.10 Summary Several 8-¿-aminoketones ("Mannich bases") have been broininated and the resulting bronioaminoketones have been converted to 2-aminothiazoles. The structures of the bromination
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.