Backround/Aim. Laryngeal carcinomas make 1-3% of all head and neck malignancies.Treatment outcome and survival rates depend greatly on established stage of the disease. The purpose of this paper was to examine the survival of the patients with advanced laryngeal carcinoma depending on gender, age, common risk factors (tobacco and alcohol use), primary tumor localization, histopathological tumor grade, clinical TNM stage and surgical treatment of the disease. Methods. Retrospective study included 252 patients treated surgically for advanced squamocellular carcinoma of the larynx in a threeyear period with five-year follow up. Patients included in the study were treated primary with surgery, with postoperative radiotherapy and chemotherapy depending on the stage of the disease, intraoperative findings and tumor resection borders. Overall survival and disease-specific five-year survival of patients was calculated for demographical and clinical characteristics of the patients. Results. Overall 5-year survival for patients with operable advanced laryngeal cancer included in the study was 86.14% and disease-specific survival 86.51%. Lower overall and disease-specific survival was associated with age, higher histological tumor grade and more extensive neck dissections. Conclusion Primary total laryngectomy results in higher survival outcomes in cases of transglottic T3 and T4a laryngeal tumors. Patients should be informed of the likely increased mortality risks tied to the choice of surgical resection and treatment modality before their decision. Running title: Survival in advanced laryngeal cancerApstrakt Uvod / Cilj. Karcinomi larinksa čine 1-3% svih maligniteta glave i vrata. Terapijski rezultati i preživljavanje umnogome zavisi od stadijuma bolesti. Cilj rada bio je da se ispita preživljavanje pacijenata hirurški lečenih od odmaklih karcinoma larinksa u zavisnoti od starosti, pola, uobičajenih faktora rizika (pušenje, konzumiranje alkohola), primarne lokalizacije tumora, histopatološkog stadijuma bolesti, TNM stadijuma bolesti, I primenjene hirurške terapije bolesti. Metode. Retrospektivna studija je sprovedena na 252 pacijenata hirurški lečenih od odmaklih sa periodom praćenja od 5 godina. Pacijenti uključeni u studiju su primarno lečeni hirurški, sa sprovođenjem postoperativne radioi hemioterapije, u zavisnosti od lokalne I regionalne proširenosti bolesti, intraoperativnog nalaza i linija resekcija granica. Petogodišnje ukupno preživljavanje I preživljavanje bez znakova bolesti je kalkulisano u zavisnosti od demografskih I kliničkih karakeristika pacijenata. Rezultati. Ukupno petogodišnje preživljavanje pacijenata sa odmaklim karcinomima larinksa je iznosilo 86.14%, a petogodišnje preživljavanje bez znakova bolesti 86.51%. Smanjeno preživljavanje je bilo značajno povezano sa starošću pacijenata, višim histloškim gradusom tumora I opsežnijim disekcijama vrata. Zaključak. Primarna totalna laringektomija rezultira dužim preživljavanjem u slučajevima transglotisnih T3 i T4a tumorima larinksa. Pacijenti, pre donešenja ...
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