Electrochemical biosensors are promising
technologies for detection
and monitoring in low-resource settings due to their potential for
easy use and low-cost instrumentation. Disposable gold screen-printed
electrodes (SPEs) are popular substrates for these biosensors, but
necessary dopants in the ink used for their production can interfere
with biosensor function and contribute to the heterogeneity of these
electrodes. We recently reported an alternative disposable gold electrode
made from gold leaf generated using low-cost, equipment-free fabrication.
We have directly compared the surface topology, biorecognition element
deposition, and functional performance of three disposable gold electrodes:
our gold leaf electrodes and two commercial SPEs. Our leaf electrodes
significantly outperformed the SPEs for reproducible and effective
biosensing in a DNase I assay and are nearly an order of magnitude
less expensive than the SPEs. Therefore, these electrodes are promising
for further development as point-of-care diagnostics, especially in
low-resource settings.
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