We evaluated the efficiency of using a 308‐nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received treatment with excimer laser and halometasone had significantly higher rates of repigmentation, even higher than individuals who were treated with tacrolimus combined or pimecrolimus combined. This regimen was more effective on the face, neck, and limbs. We conclude that the use of a combined excimer laser and halometasone cream has a greater therapeutic effect than laser alone.

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Invasion and metastasis of melanoma are a series of complicated biological events regulated by multiple factors. The coregulation of many molecules involved in the development and progression of melanoma contributes to invasion and migration. mGluR1 is a metabotropic glutamate receptor that is overexpressed in melanocytes and is sufficient to induce melanoma. In our study, we found that mGluR1 was obviously increased in melanoma. Furthermore, we found that miR-129-5p could directly target and regulate mGluR1 mRNA, which was significantly reduced in A375 cells. Overexpression of miR-129-5p inhibited cell migration, invasion and clonal formation. lncRNA-AC130710 directly targeted and suppressed miR-129-5p in A375 cells. Downregulation of lncRNA-AC130710 suppressed the levels of mGluR1 mRNA by promoting miR-129-5p expression and further inhibiting migration, invasion and colony formation in A375 cells, which was associated with the activation of the PKCα-MAPK signaling pathway. Taken together, our study showed that the lncRNA-AC130710/miR-129-5p/mGluR1 axis plays an important role in the invasion and metastasis of melanoma.

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Background: It is unknown how the identification of undiagnosed DM (UDM) among Chinese changes the estimation of atherosclerotic cardiovascular disease (ASCVD) risk using the Chinese and the U.S. risk calculators. Methods: We included 1884 adults aged 30-75 free of ASCVD from 4 urban and rural communities in Shanxi Province, China. UDM was defined as newly found DM by glucose or HbA1c with no DM history or DM medication. 10-year ASCVD risk was estimated using the Prediction for ASCVD Risk in China (China-PAR) score and 2013 AHA/ACC Pooled Cohort Equation (PCE) and classified into risk categories. For those with UDM, the risk scores were calculated before and after DM diagnosis. Results: Among 266 (14.1%) DM patients, 161 (8.5%) were UDM. Compared to those with diagnosed DM, those with UDM had milder DM and better CVD risk profiles. The mean China-PAR among non-DM, UDM (before diagnosis) and diagnosed DM were 6.0% 14.3% and 18.8% and mean PCE were 2.5%, 5.3% and 13.0%, respectively. Among those with UDM, the mean China-PAR and PCE increased to 16.7% and 9.2% after DM diagnosis (both p <0.0001); 6.2% and 34.8% were reclassified into higher risk groups according to the Chinese and U.S. guidelines (Figure). Conclusion: Identification of UDM had greater impact on estimated ASCVD risk using PCE than China-PAR among Chinese and may change the preventive treatment by risk reclassification. Disclosure J. Yang: None. Y. Zhao: None. Y. Ren: None. L. Lan: None. L. Xu: None. J. Yin: None. Q. Xu: None. Y. Li: None. Funding Research Fund for Public Welfare, National Health, and Family Planning Commission of China (201402005)