The objective of this review is to investigate the short-and long-term effects of osteopathic manipulative treatment on cardiovascular function and its regulators in the nervous and endocrine systems.Introduction: A variety of pharmacological and lifestyle-based treatments are used to prevent or treat vascular diseases, yet vascular disease underpins the top 2 causes of death worldwide. There is a need for more preventative and therapeutic interventions in the management and prevention of vascular disease that are compatible with existing interventions. Osteopathic manipulative treatment has shown promise as a non-invasive approach to improve cardiovascular function, but it is currently utilized mostly for alleviating musculoskeletal symptoms. A comprehensive summary of the evidence on the effectiveness of osteopathic manipulative treatment in cardiovascular function will assist clinicians and guide future research directions.Inclusion criteria: This review will consider randomized controlled trials, non-randomized controlled trials, and crossover studies. Participants must have received osteopathic manipulative treatment intervention. Comparators will include passive or active controls, including controls for body position, touch, and other potential interventions for vascular disease. Cardiovascular, nervous-system, or endocrine-system outcome variables must be measured at least once after treatment. Adverse events will also be considered.
Background and PurposeOsteopathic cranial manipulations (CM) have been used as a part of therapeutic management of hypertensive patients. However, our knowledge about physiological responses to CM in cardiac patients is limited. A quantitative relationship between applied CM and cardiovascular parameters has not been well established. The purpose of this study was to measure changes in heart rate, autonomic input to the heart by using the heart rate variability test, cardiac contractility by using impedance cardiography, and systemic blood pressure in response to selected CM, namely occipital‐atlantal decompression, occipital‐mastoid decompression, and compression of the fourth ventricle.MethodHypertensive 65–75 year old subjects, three men and two women, were involved in this study. Hypertension was controlled by an angiotensin‐converting enzyme inhibitor (3 subjects), calcium channels blocker (1 subject) and beta‐blocker (1 subject). Each subject participated in the experimental (CM) and control (sham) groups. A non‐invasive impedance cardiography method was used to measure changes in cardiac parameters before and after manipulations. Data were recorded and analyzed using BIOPAC Systems, Inc. equipment and software. Blood pressure was measured before and after manipulations by using a sphygmomanometer. All manipulations were performed by the same osteopathic physician.ResultsCranial and sham manipulations resulted in different responses by the subjects. CM produced a decrease in systolic (5%) and mean arterial (6%) pressures, and revealed a trend towards an increase in sympathetic and decrease in parasympathetic cardiac activity based on heart rate variability test. Sham manipulations did not affect blood pressure and were associated with a trend towards a decrease in sympathetic and increase in parasympathetic cardiac activity. No changes in cardiac contractility were recorded for CM and sham manipulations.Discussion and conclusionIt appears that cranial manipulations may enhance the antihypertensive effect of medication through the effect on autonomic nervous system. The physiological effect of CM on autonomic control of systemic hemodynamics needs further investigation.Support or Funding InformationThis project was funded by the TUN Research Grant AwardThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
This study was aimed to determine if there is a correlation between accumulation of various Alzheimer's disease (AD) markers in the brain and retina of individuals in the late stages of the disease. Characterizing the distribution and accumulation of these markers in the retina and brain may be important for early diagnosis of neurodegenerative diseases such as AD.We examined total tau and phosphorylated tau protein accumulations in different areas of the brain and in retinal tissues from aged individuals with AD in order to compare the intensity and sensitivity of these biomarkers.Tissues from the hippocampus and temporal lobe of four different cadavers were analyzed. Two cadavers had diagnosed Alzheimer's disease, and two cadavers served as a non‐AD control. We utilized cryosectioning to prepare tissue sections for immunostaining. Tissues obtained from individuals without a history of Alzheimer's disease or other types of dementia were used as negative controls. Detection of tau was performed using a primary antibody against human tau proteins and amyloid‐b, followed by a universal secondary antibody.Although the staining for AD markers was greater than controls for both brain tissues, the density was higher in the hippocampus than in the temporal lobe. The density of the total tau (TT) was greater than that of phosphorylated tau (PT181) in both the hippocampus and temporal lobe. We also found this to be the case in the brain tissues of a control, indicating that total tau may be a more sensitive biomarker than phosphorylated tau.These data demonstrate that total tau may be a stronger biomarker than phosphorylated tau in quantifying protein accumulations in the brains of Alzheimer's disease cadavers. This raises the intriguing possibility that there may be more sensitive biomarkers that can better predict the course of neurodegenerative diseases such as AD. Thus, future studies will concentrate on the accumulation of tau in the brain and retina of individuals during the earlier stages of Alzheimer's disease, as well as the sensitivity and accuracy of different biomarkers.Support or Funding InformationTouro University Nevada intramural grant.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.