This study was conducted to evaluate the effect of different feed additives (Probiotics, Prebiotic, Synbiotic, Organic acids and Enzymes) on productive and economic efficiency of Cobb and Ross broiler breeds. A total of 576 healthy unsexed one-day-old broiler chicks (Cobb and Ross breed) were allocated randomly in to 12 groups, 6 groups for each breed. Each group consisted of three replicates (total 36 replicates for all groups). The results showed that the highest body weight at 42 days of age was found for synbiotic and organic acid groups for Cobb breed (2050 and 2105.70 gm, respectively). Cobb breed showed higher body weight than Ross breed from the first day of age till the end of experiment. The value of total return was the highest for organic acid groups of both Cobb and Ross breed (L.E 27.72 and 27.41, respectively) and for Synbiotic groups (L.E 27.0 and 27.26 respectively), while the lowest value was found for the enzyme group of Cobb breed (L.E 25.16).The value of net profit was the highest for synbiotic group of Ross breed and organic acid group of Cobb breed (L.E 5.35 and 4.95 /chicken, respectively). On the basis of our results, it would be concluded that organic acids and synbiotic feed additives were better than other used feed additives, and they had an important role in improving productive and economic efficiency of broiler chicks.