Increasing the permeability of drugs across the cornea is key to improving drug absorption by the eye. This study presents a newly developed in situ gel loaded with nanoparticles, which could achieve controlled drug release and high ocular drug bioavailability by avoiding rapid precorneal clearance. The physicochemical parameters of the formulation were investigated and showed uniform size, physical stability, and favorable rheological and gelling properties. Ex vivo permeation studies revealed significantly higher drug release from the in situ gel loaded with nanoparticles compared to the conventional poloxamer in situ gel and the drug solution. When compared with a marketed formulation, the in situ gel loaded with nanoparticles provided slower controlled release and higher ocular bioavailability of dexamethasone. In conclusion, the developed nanoparticle-loaded in situ gel can successfully increase drug ocular bioavailability by enhancing contact time with the ocular surface and permeation through the cornea.
With the popularization and rise in BIM technology usage, BIM education for undergraduate students in architecture, engineering, and construction (AEC) related disciplines has emerged as a priority. This study assesses the BIM learning outcomes of students participating in the National BIM Graduation Design Innovation Competition of Colleges and Universities. In total, 2777 valid questionnaire responses were obtained for this study. The Cronbach’s alpha coefficient method and principal component factor analysis method were used to verify the reliability of the data set (Cronbach’s alpha = 0.962, KMO = 0.965). The t-test (ANOVA) was used to verify that gender, school type, major, grade, study duration and use BIM related software, as well as other demographic attributes, displayed significant inter-group differences. Seven common factors affecting BIM learning performance were obtained by exploratory factor analysis: (1) ability of the instructor, (2) school (college) atmosphere, (3) teamwork, (4) individual ability, (5) understanding of BIM industry applications, (6) social environment incentives, and (7) achievement demand. Finally, the results of an ordered logistic regression revealed that the demographic attributes of participants, the comprehensive ability of the instructor, teamwork, individual ability, and achievement demand significantly affects BIM learning performance. Based on these findings, this paper puts forward suggestions for improving BIM learning performance and provides theoretical support for BIM education and learning in AEC related undergraduate majors.
The global climate change has resulted in huge flood damages, which seriously hinders the sustainable development of rural economy and society and causes famers’ livelihood problems. In flood-prone areas, it is imperative to actively study short and long-term strategies and solve farmers’ livelihood problems accordingly. Following the sustainable development analysis framework proposed by the Department for International Development (DFID), this study collects empirical data of 360 rural households in six sample villages in the Jialing River Basin of Sichuan Province, China through a village-to-household field questionnaire and applies the Multinominal Logit Model (MNL) to explore the influence of farmer households’ capital on livelihood strategy choice. Research results show that: (1) In human capital category, the education level of the household head has a significant positive impact on the livelihood strategies of farmers’ families; (2) In physical capital category, farmer households with larger space have more funds to choose among flood adaptation strategies; (3) In natural capital category, house location and the sale of family property for cash have the greatest negative impact on farmers’ livelihood strategies; (4) Rural households with more credit opportunities in financial capital are more willing to obtain emergency relief funds; (5) Farmers’ families helped by the village for a long time will probably not choose to move to avoid floods, but are more likely to choose buying flood insurance. This study provides an empirical reference for effective short and long term prevention and mitigation strategies design and application in rural in flood-prone areas.
Earthquake is one of the most serious natural disasters. Taking scientific and reasonable earthquake preparedness measures can effectively reduce casualties and economic losses caused by earthquakes. It is important to understand how residents choose such earthquake preparedness measures to guide them accordingly. However, the current research has failed to address rural areas in developing countries and has inconsistency conclusions for two aspects related to stakeholders involved: the assistance the victims can get from stakeholders for applying earthquake preparedness measures and the trust in stakeholders’ disaster relief abilities. In this study, the rural residents affected by Wenchuan earthquake, Ya’an earthquake and Yibin earthquake were taken as the research objects, and 674 valid questionnaires were obtained through field household surveys. A Multinominal Logit Model (MNL) was constructed to explore the influence of villagers’ trust in the disaster relief ability of stakeholders and the help they can get from stakeholders on their preparedness behavior. The results show that the less trust the villagers have on the government and the community, and the more help they can get from the outside while preparing measures, the more inclined they are to take the disaster preparedness measures. Furthermore, the education level of villagers in earthquake-stricken areas has significant positive impacts on people’s earthquake preparedness behavior. People who are not born in rural areas are more likely to take earthquake preparedness measures. In addition, male, young and married villagers are more likely to take earthquake preparedness measures in their daily lives. This study enriches the theory of rural disaster prevention and mitigation, and provides reference for the practice of disaster prevention and mitigation in earthquake-stricken rural areas.
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