Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.
O objetivo desse estudo é explicar três patologias próximas que manifestam-se em crianças na sua primeira infância, contribuindo com nutricionistas e pediatras e incentivando um trabalho multidisciplinar. O erro genético raro que acomete os neonatais e impossibilita a metabolização da galactose é denominado como Galactosemia clássica. A reação imunológica do corpo a exposição precoce das crianças a determinadas proteínas, como a caseína e lactoglobulina, é conhecida como Alergia à proteína do leite de vaca. E por fim, a Intolerância à lactose que é subdividida em primária, secundária e congênita, sendo esta a mais comum em crianças impossibilitando a produção da enzima que faria a absorção da lactose. Apresentará uma revisão bibliográfica sobre as possíveis terapêuticas adequadas evitando deficiências nutricionais em consequência da necessidade de restrição ou exclusão do alimento leite nas suas dietas. A pesquisa utilizou um total de 33 artigos encontrados nas bases Science, Scielo e Google Acadêmico.
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