The aim of this study was to describe the prevalence of adverse drug events (ADEs) and associated factors reported by users of medicines in Brazil. This was a cross-sectional population-based study conducted from September 2013 to February 2014 with data from the Brazilian National Survey on Access, Use, and Promotion of Rational Use of Medicines (PNAUM). The study included all individuals that reported the use of medicines and identified, among them, all those reporting at least one problem with the medicine's use. A descriptive analysis was performed to estimate ADE prevalence and 95% confidence intervals (95%CI) among the target variables. Crude and adjusted prevalence ratios were calculated using Poisson regression to investigate factors associated with ADEs. Overall ADE prevalence in Brazil was 6.6% (95%CI: 5.89-7.41), and after multivariate analysis, higher prevalence was associated with female gender, residence in the Central and Northeast regions, consumption of more medicines, "bad" self-rated health, and self-medication. The drugs most frequently reported with ADEs were fluoxetine, diclofenac, and amitriptyline. The most frequent ADEs were somnolence, epigastric pain, and nausea. Most reported ADEs were mild, avoidable, and associated with medicines used frequently by the population. The study provided knowledge on the size of the problem with use of medicines in Brazil.

ResumoMuitas são as técnicas propostas à obturação dos Sistemas de Canais Radiculares (SCR), todavia, nenhuma delas alcançam o completo selamento. Em 2013, foi introduzido o cone auto-ajustável CPoint, que promete adaptar-se às paredes de canais produzindo obturações obturação dos SCR. Foi utilizada a base de dados PubMed, usando os descritores Endodontics, Obturation e\ou CPoint, nos últimos 10 anos. Encontrou-se 5 estudos, os quais foram incluídos na revisão. Dentre as avaliações, analisou-se sua biocompatibilidade, porções principais: um núcleo central que confere características de inserção e um revestimento polimérico hidrofílico que expande radialmente até encontrar às paredes dos canais. Tanto a expansão do CPoint quanto a presa do cimento dão-se pela absorção da umidade presente no SCR. Em outros testes, proporcionou uma maior resistência à fratura das raízes obturadas, contudo, demonstrou para uso clínico.Palavras-chave: Endodontia. Materiais Dentários. Obturação do Canal Radicular.