Vitamin D receptor (VDR) mediates various biochemical activities between the cytoplasm and the nucleus in the cell. The nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) protein is involved in the T helper type 2 (Th2) response. This study tests a hypothesis that VDR interacts with NLRP3 to restrict the Th2-biased response. In this study, VDR mice and WT (WT) mice were used. Th2 cell differentiation between VDR mice and WT mice was observed. We observed that CD4 T cell activation was higher in VDR mice. The VDRCD4 T cells were prone to Th2 polarization. VDR mice produced more immunoglobulin (Ig)E. VDR bound NLRP3 to prevent Th2 differentiation by restricting IL4 gene transcription. Th2 biased inflammation spontaneously developed in the intestine of VDR mice. In conclusion, VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization.
This article presents theoretical studies for parametrically excited vibrations of marine riser of the floating production, drilling, storage, and offloading system under random wave forces and earthquake excitation. The equation of motion of the riser is obtained by a mathematical method utilizing Euler beam theory and Galerkin method. The trigonometric series method is used to formulate random wave force and earthquake excitation in time domain. The dynamic analysis, spectral response analysis, and key parameters’ sensitivity analysis are conducted for the riser system. Parameter studies are conducted for the effects of wave and earthquake parameters and structural parameters on dynamics response of the riser system. The results from this study can provide valuable recommendations for the design and construction of the parametrically excited marine riser system under random wave forces and earthquake excitation and can promote widely practical application of the deep water riser in complicated environmental conditions.
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