Hydrazine (NH 2 NH 2 ) is a highly toxic organic substance that poses a threat to human health. Monitoring hydrazine with high sensitivity and selectivity is very important.Here, a simple colorimetric fluorescent probe for hydrazine detection, which is a seminaphthorhodafluor derivative containing thiophene-2-carboxylic acid ester reaction site, was rationally constructed. The probe itself exhibits weak fluorescence. The fluorescence is significantly enhanced when hydrazine is added. The probe exhibited a broad linear range (0-1 mM) with satisfactory selectivity and sensitivity (limit of detection 36.4 μM), which turned out to be an excellent fluorescent probe for monitoring hydrazine. Additionally, the probe was used to track hydrazine in living cells and zebrafish with great success, and the detection performance was satisfying.These results proved that this type of fluorescent probe with the thiophene-2-carboxylic acid ester structure can detect hydrazine with higher selectivity and sensitivity.
Bisulfite (HSO 3À ) is associated with many physiological processes in living systems. High concentration of HSO 3 À may lead to many diseases. Herein, a simple levulinate-based colorimetric fluorescent probe for HSO 3 À detection was designed and synthesized. The probe showed high selectivity for HSO 3 À detection with color changes from light pink to deep pink.Under the optimal test conditions, there is a good linear relationship between fluorescence intensity and concentrations of HSO 3 À in the range of 0-50 μM with detection limit of 1.04 nM. In addition, the probe was successfully applied to monitor HSO 3 À in living cells and zebrafish, which proved that the probe can be used to detect HSO 3 À in living systems.
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