Thermally activated delayed fluorescence emitters with small energy gap between the triplet and singlet (ΔEST ), TXO-PhCz and TXO-TPA, have been successfully synthesized by combining a hole-transporting TPA/PhCz moiety and an electron-transporting TXO moiety. Both compounds display efficient solid-state luminescence with an efficient up-conversion of the triplet to singlet. OLEDs based on them exhibt high performance up to 21.5%, which is among the best reported for OLEDs.
The Lewis acid/base passivation strategy and its effects on energy level alignment, recombination kinetics, hysteresis behavior and operational stability for efficient perovskite solar cells are comprehensively reviewed.
Rationale:
The forkhead box A1 (FOXA1) is a crucial transcription factor in initiation and development of breast, lung and prostate cancer. Previous studies about the FOXA1 transcriptional network were mainly focused on protein-coding genes. Its regulatory network of long non-coding RNAs (lncRNAs) and their role in FOXA1 oncogenic activity remains unknown.
Methods:
The Cancer Genome Atlas (TCGA) data, RNA-seq and ChIP-seq data were used to analyze FOXA1 regulated lncRNAs. RT-qPCR was used to detect the expression of DSCAM-AS1, RT-qPCR and Western blotting were used to determine the expression of FOXA1, estrogen receptor α (ERα) and Y box binding protein 1 (YBX1). RNA pull-down and RIP-qPCR were employed to investigate the interaction between DSCAM-AS1 and YBX1. The effect of DSCAM-AS1 on malignant phenotypes was examined through
in vitro
and
in vivo
assays.
Results:
In this study, we conducted a global analysis of FOXA1 regulated lncRNAs. For detailed analysis, we chose lncRNA DSCAM-AS1, which is specifically expressed in lung adenocarcinoma, breast and prostate cancer. The expression level of DSCAM-AS1 is regulated by two super-enhancers (SEs) driven by FOXA1. High expression levels of DSCAM-AS1 was associated with poor prognosis. Knockout experiments showed DSCAM-AS1 was essential for the growth of xenograft tumors. Moreover, we demonstrated DSCAM-AS1 can regulate the expression of the master transcriptional factor FOXA1. In breast cancer, DSCAM-AS1 was also found to regulate ERα. Mechanistically, DSCAM-AS1 interacts with YBX1 and influences the recruitment of YBX1 in the promoter regions of FOXA1 and ERα.
Conclusion:
Our study demonstrated that lncRNA DSCAM-AS1 was transcriptionally activated by super-enhancers driven by FOXA1 and exhibited lineage-specific expression pattern. DSCAM-AS1 can promote cancer progression by interacting with YBX1 and regulating expression of FOXA1 and ERα.
Hydrotalcite-supported platinum nanocrystals (Pt NCs) were synthesized by a facile solution chemistry method, and then applied as an efficient catalyst for the selective hydrogenation of cinnamaldehyde (CMA) in neat water. The reduction of metal precursor ions was achieved in an aqueous solution at a low temperature (323 K), simultaneously accompanied by the crystallization of the hydrotalcite support. The size of the Pt NCs can be delicately tuned by the relative ratio of surfactant to metal precursor ions, and characterized by HRTEM and CO-adsorption infrared spectroscopy. The Pt particle sizes are closely associated with the hydrogenation selectivity toward cinnamyl alcohol (CMO), with a higher selectivity up to 85% over the larger-sized Pt in an aqueous medium. The effects of alkali (NaOH) on the catalytic performance were explored. The findings indicated that the addition of alkali enhances the selectivity toward CMO (to 90%). The catalysts showed high stability with a marginal decrease in activity and selectivity after repeated use. The hydrogenation products could be easily separated from the solvent by simple extraction, which is a greener and more convenient process than those using organic solvents.
Tin
dioxide (SnO2) as an efficient electron transport
layer (ETL) has been demonstrated for emerging high-performance organic–inorganic
hybrid perovskite solar cells (PSCs). However, the low-temperature
solution-processed SnO2 usually results in high trap-state
density and current–voltage hysteresis. Here, we reported an
effective strategy to solve this problem by incorporating graphene
ink into the low-temperature processed SnO2 for planar
structure PSCs. The electron extraction efficiency has been significantly
improved with graphene-doped SnO2 ETL coupled with attenuated
charge recombination at the ETL/perovskite interface. The power conversion
efficiency (PCE) of PSCs based on the graphene–SnO2 ETL reached over 18% with negligible hysteresis. Incorporation of
graphene into the ETL layer also enhanced the device stability retaining
90% of the initial PCE value after storing in ambient condition with
a relative humidity of 40 ± 5% for 300 h. Our results provide
an important insight into further efficiency boost in SnO2-based low-temperature processed PSCs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.